Table 1 National Institute of Allergy and Infectious Disease and Food Allergy and Anaphylaxis Network criteria for anaphylaxis
Anaphylaxis is likely when any one of these three criteria is fulfilled: |
|---|
1. Acute onset of illness (minutes to several hours) with involvement of the skin, mucosal tissue, or both (e.g., generalized hives, pruritus or flushing, swollen lips, tongue, or uvula) |
and at least one of the following: |
 (a) Respiratory compromise (e.g., dyspnea, wheeze or bronchospasm, stridor, reduced peak expiratory flow, hypoxemia) |
 (b) Reduced blood pressure or associated symptoms of end-organ dysfunction (e.g., hypotonia [collapse], syncope, incontinence) |
2. Two or more of the following that occur rapidly after exposure to a likely allergen for that patient (minutes to several hours): |
 (a) Involvement of the skin or mucosal tissue (e.g., generalized hives, itch or flush, swollen lips, tongue, or uvula) |
 (b) Respiratory compromise (e.g., dyspnea, wheeze or bronchospasm, stridor, reduced peak expiratory flow, hypoxemia) |
 (c) Reduced blood pressure or associated symptoms (e.g., hypotonia [collapse], syncope, incontinence) |
 (d) Persistent gastrointestinal tract symptoms (e.g., crampy abdominal pain, vomiting) |
3. Reduced blood pressure after exposure to known allergen for that patient (minutes to several hours): |
 (a) Infants and children: low systolic blood pressure (age specific) or >30% decrease in systolic blood pressurea |
 (b) Adults: systolic blood pressure <90 mmHg or >30% decrease from that person’s baseline |