Table 6 Mean (range) ECG measurements (HR and QTc interval), serum potassium level and BSL for each tertile of albuterol enantiomer serum level
Albuterol concentration (range) | (R)-albuterol Lower (0.0-1.2 ng/mL) Middle (1.3-2.5 ng/mL) Upper (2.8-16.7 ng/mL) | (S)-albuterol Lower (0.0-2.1 ng/mL) Middle (2.5-6.8 ng/mL) Upper (6.9-36.3 ng/mL) | Total albuterol Lower (0.0-3.1 ng/mL) Middle (3.2-9.7 ng/mL) Upper (9.9-53.0 ng/mL) |
|---|---|---|---|
HR (/min) (n = 26) | 89 (70-120) 103 (59-127) 109 (96-137) | 88 (70-120) 102 (59-120) 109 (96-137) | 89 (70-120) 102 (59-120) 109 (100-137) |
QTc interval (ms) (n = 26) | 425 (386-486) 438 (374-481) 384 (363-404) | 425 (374-481) 413 (377-486) 385 (363-427) | 425 (386-481) 427 (374-486) 385 (363-406) |
Serum potassium level (mmol/L) (n = 10) | 4.7 (4.4-5.3) 3.5 (-) 4.4 (4.1-5.1) | 4.0 (3.9-5.3) 4.1 (3.5-5.1) 4.4 (3.9-5.0) | 4.0 (3.9-5.3) 3.8 (3.5-4.1) 4.6 (3.9-5.0) |
BSL (mmol/L) (n = 15) | 6.7 (5.2-13.3) 6.0 (5.4-7.8) 7.3 (5.7-10.4) | 6.7 (5.2-13.3) 6.7 (5.8-7.8) 6.2 (5.4-10.4) | 6.7 (5.2-13.3) 6.1 (5.4-7.8) 6.8 (5.7-10.4) |