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Table 2 Complement profiles involved in each type of angioedema

From: Emerging concepts in the diagnosis and treatment of patients with undifferentiated angioedema

Angioedema type

Urine histamine

Serum tryptase

C4 level

C1-INH Level (antigenic)

C1-INHLevel (functional)

C1q level

C3 level

Histamine-mediated angioedema

NL

NL

NL

NL

NL

Hereditary angioedema types I and II

NL

NL

↓ (type I)

NL

NL

NL (type II)

Hereditary angioedema type III

NL

NL

NL

NL

NL

NL

NL

Acquired angioedema

NL

NL

↓ or NL

↓ or NL

ACE inhibitor-induced angioedema

NL

NL

NL

NL

NL

NL

NL

Idiopathic angioedema

NL

NL

NL

NL

NL

NL

NL

Pseudoallergic angioedema

NL

NL

NL

NL

NL

NL

NL

  1. ACE angiotensin-converting enzyme, C3 complement factor 3, C4 complement factor 4, C1-INH C1 esterase inhibitor, NL normal.