Outcome predictors of uncomplicated sepsis

ter Avest, Ewoud; de Jong, Maarten; Brűmmer, Ineke; Wietasch, Götz JK; ter Maaten, Jan C

doi:10.1186/1865-1380-6-9

International Journal of Emergency Medicine

Table 1 Clinical and biochemical characteristics of survivors and non-survivors of uncomplicated sepsis at the emergency department

From: Outcome predictors of uncomplicated sepsis

	n	Survivors (n= 62)	Non-survivors (n= 8)	p
		n[%]	n[%]
Demographics and history
Gender (M/F)	70	35/27	4/4	0.51
Age (years)	70	57 ± 19	71 ± 9	0.04
Underlying predisposing condition for adverse course of sepsis*	70	39 [63%]	8 [100%]	0.42
Immunocompromised state**	70	22	4	0.73
Nursing home resident	70	1 [2%]	1 [12%]	0.24
Terminal illness	70	1 [12%]	1 [12%]	0.24
Relevant medication use
Immunosuppressive drugs (n)	70	19 [31%]	1 [12%]	0.68
Maintenance antibiotics (n)	70	5 [8%]	1 [12%]	0.54
β-blockers (n)	70	12 [19%]	6 [75%]	<0.01
Other vasoactive medications	70	18 [29%]	3 [38%]	0.71
Statins	70	15	1	1.00
Site of infection
Lower respiratory tract infection	70	35	6	0.77
Urinary tract infection	70	10	2	0.64
Other	70	17	0	0.35
Vital signs
Altered mental state (GCS <15)	70	0	1	0.13
Heart rate (bpm)	70	109 ± 18	101 ± 19	0.34
Respiration rate (rpm)	70	24 ± 6	22 ± 5	0.14
Temperature (°C)	70	38.3 ± 1.0	37.8 ± 1.6	0.32
SBP (mmHg)	70	131 ± 26	132 ± 30	0.62
DBP (mmHg)
MAP (mmHg)	70	91 ± 16	95 ± 20	0.84
Oxygen saturation (%)	70	94 ± 4	95 ± 3	0.58
Laboratory values
Hb (mmol.l^-1)	70	7.7 ± 1.4	6.6 ± 1.2	0.03
Ht (%)	70	36 ± 0.10	35 ± 0.09	0.94
Platelet count (×10⁹.l^-1)	69	251 ± 160	243 ± 179	0.77
White blood cell count (×10⁹.l^-1)	70	13.0 ± 6.2	8.5 ± 4.7	0.06
CRP (mg.l^-1)	70	110 ± 98	113 ± 90	0.90
Creatinine (umol.l^-1)	70	83 ± 49	79 ± 20	0.58
BUN (mmol.l^-1)	70	6.3 ± 3.3	9.2 ± 3.6	0.14
Bilirubin (mmol.l^-1)	49	18 ± 21	21 ± 12	0.93
Glucose (mmol.l^-1)	61	7.2 ± 2.5	6.3 ± 1.0	0.23
Arterial lactate (mmol.l^-1)	45	1.1 ± 0.5	1.3 ± 0.2	0.57
Treatment characteristics
Time to antibiotics (min)	47	88 ± 54	80 ± 51	0.85
Fluid administration first 120 min (ml)	62	688 ± 586	625 ± 627	0.89
Abbrev. MEDS score	70	4.8 ± 2.9	7.2 ± 3.4	0.03

Data are presented as mean ± SD. GCS, Glasgow coma scale; SBP, systolic blood pressure; MAP, mean arterial pressure; Hb, hemoglobin; CRP, C-reactive protein; BUN, blood urea nitrogen.
* See Table 2.
** Immunocompromised state was considered present if a patient had any of the following: HIV or AIDS, leukemia, any malignancy, any history of chemotherapy, neutropenic fever, non-Hodgkin’s lymphoma, transplanted organ, or current use of steroid or other immunosuppressive drugs.

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ISSN: 1865-1380

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