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Table 1 Modified definitions for organ dysfunction

From: Predictors of early progression to severe sepsis or shock among emergency department patients with nonsevere sepsis

Organ dysfunction Original definitions Modified definitions
Respiratory paO2/FiO2 < 300 Intubation
Renal Creatinine increase >0.5 mg/dL or urine output <0.5 mL/kg/h for at least 2 h Creatinine increase >0.5 mg/dLa
Coagulopathy INR >1.5 or aPTT >60 s n/a
Hematologic Platelet count <100,000/uL n/a
Liver Total bilirubin >4 mg/dL n/a
  1. paO2 arterial partial pressure of oxygen, FiO2 fractional oxygen percentage, INR international normalized ratio, aPTT activated partial thromboplastin time
  2. aIf a patient did not have a prior visit and the initial creatinine >2.0 mg/dL, we assessed if there was a >50 % decrease in creatinine in the first 96 h of hospital care