The effectiveness of rapid sequence intubation (RSI) versus non-RSI in emergency department: an analysis of multicenter prospective observational study

Table 4 Multivariable associations of intubation methods with intubation outcomes

	Success on 1st attempt, adjusted OR (95% CI) P value	Success ≤2nd attempt, adjusted OR (95% CI) P value	Complications^c, adjusted OR (95% CI) P value	Major complications^d, adjusted OR (95% CI) P value
RSI versus non-RSI
Multivariable model adjusting for selected variables^a	2.1 (1.7–2.6) P < 0.0001	1.8 (1.4–2.6) P < 0.0001	1.0 (0.7–1.3) P = 0.76	1.0 (0.7–1.5) P = 0.76
Multivariable model adjusting for selected variables and clustering of patients^b	2.3 (1.8–2.9) P < 0.0001	1.9 (1.1–3.0) P < 0.0001	0.9 (0.6–1.2) P = 0.31	0.9 (0.6–1.3) P = 0.53
Stratified analysis by non-RSI methods adjusting for selected variables^a
RSI vs. intubation with sedative agent only	2.2 (1.7–2.8) P < 0.0001	2.2 (1.6–3.0) P < 0.0001	0.8 (0.6–1.2) P = 0.30	0.9 (0.6–1.3) P = 0.63
RSI vs. intubation without medications	2.0 (1.6–2.6) P < 0.0001	1.5 (1.0–2.1) P = 0.03	1.1 (0.8–1.5) P = 0.54	1.2 (0.8–1.9) P = 0.35

Abbreviation: OR odds ratio, CI confidence interval, RSI rapid sequence intubation
^aAdjusted for age, sex, estimated body weight, principal indication for intubation, device, and the specialties and training level of intubator
^bAdjusted for age, sex, estimated body weight, principal indication for intubation, device, the specialties and training level of intubator, and potential clustering of patients within EDs with random effects model
^cDefined as cardiac arrest, hypotension, hypoxemia, regurgitation, esophageal intubation with delayed recognition, main stem bronchial intubation, dental or lip trauma, airway trauma, or allergic reaction
^dDefined as cardiac arrest, hypotension, hypoxemia, regurgitation, or esophageal intubation

ISSN: 1865-1380