From: Markers of diuretic resistance in emergency department patients with acute heart failure
Number | Normal (N = 155) | Diuretic resistant (N = 32) | p value | |||
---|---|---|---|---|---|---|
Age | 187 | 63 | (54, 73) | 68 | (62, 77) | 0.031 |
Sex | 187 | 0.62 | ||||
Female | 36% | 56 | 31% | 10 | ||
Male | 64% | 99 | 69% | 22 | ||
Race | 187 | 0.0562 | ||||
AA | 54% | 82 | 34% | 11 | ||
Other | 47% | 73 | 66% | 21 | ||
History of renal disease | 184 | 0.33 | ||||
No | 73% | 111 | 81% | 26 | ||
Yes | 27% | 41 | 19% | 6 | ||
Home diuretic dose (mg) | 77 | 60 | (40, 80) | 60 | (40, 80) | 0.78 |
SBP | 187 | 149 | (130, 178) | 147 | (129, 174) | 0.791 |
BUN | 185 | 21 | (15, 35) | 27 | (17, 38) | 0.161 |
Serum creatinine (baseline) | 187 | 1.4 | (1.0, 2.0) | 1.4 | (1.1, 2.1) | 0.571 |
Serum creatinine (12–24 h) | 187 | 1.5 | (1.1, 2.2) | 1.4 | (1.2, 2.1) | 0.721 |
Urine creatinine (12–24 h) | 187 | 35 | (22, 59) | 75 (46, 124) | 75 (46, 124) | <0.0011 |
eGFR | 187 | 53 | (33, 73) | 51 (30, 67) | 51 (30, 67) | 0.361 |
BNP | 187 | 1217 | (532, 2100) | 1468 | (864, 2866) | 0.151 |
Urinary sodium (12–24 h) | 187 | 99 | (82, 114) | 33 | (23, 41) | <0.0011 |
Na/K ratio | 187 | 4.5 | (2.59, 6.79) | 0.8 | (0.49, 1.41) | <0.0011 |
Serum sodium (baseline) | 187 | 140 | (138, 142) | 139 | (138, 140) | 0.111 |
Serum sodium (12–24 h) | 187 | 139 | (138, 141) | 138 | (137, 140) | 0.151 |
FeNa | 187 | 3.35 | (1.52, 5.65) | 0.73 | (0.18, 1.12) | <0.0011 |
Ejection fraction | 175 | 0.632 | ||||
Normal (greater than 55%) | 31% | (45) | 40% | (12) | ||
Mild (45–55%) | 14% | (21) | 10% | (3) | ||
Moderate (25–44%) | 23% | (33) | 27% | (8) | ||
Severe (less than 25%) | 32% | (46) | 23% | (7) | ||
ED lasix/furosemide dose categorized | 159 | 0.822 | ||||
≥80 mg | 32% | (43) | 35% | (9) | ||
<80 mg | 68% | (90) | 65% | (17) | ||
LOS (days) | 187 | 3 | (2, 6) | 4 | (3, 7) | 0.221 |
Urine output up to second visit | 172 | 1925 | (1060, 3000) | 1050 | (690, 1925) | 0.0051 |
ED revisit for HF | 187 | 0.382 | ||||
No | 87% | (135) | 81% | (26) | ||
Yes | 13% | (20) | 19% | (6) | ||
Readmission for HF | 187 | 0.032 | ||||
No | 87% | (135) | 72% | (23) | ||
Yes | 13% | (20) | 28% | (9) | ||
Status | 187 | 0.122 | ||||
Alive | 97% | (150) | 91% | (29) | ||
Deceased | 3% | (5) | 9% | (3) |