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Table 1 Medications associated with acquired methemoglobinemia

From: Acquired methemoglobinemia from phenazopyridine use

Drug class Medications implicated in cases of methemoglobinemia
Analgesics Acetaminophen (generally in overdose or combination with other oxidative stresses), Buprenorphine-naloxone, Celecoxib, Ibuprofen, Phenazopyridine
Anesthetics Benzocaine, Lidocaine, Prilocaine (including topical creams), Tetracaine
Antiemetics Metoclopramide
Antimicrobials Atovaquone, Dapsone, Sulfonamides (sulfanilamide, sulfamethoxazole, sulfapyridine, sulfathiazide), Quinolones (chloroquine, primaquine)
Vasodilators Amyl nitrate, Nitric oxide, Nitroglycerine, Nitroprusside
Xenobiotics Aniline dyes, Naphthalene, Nitrates (ex: well water contamination), Nitrites (ex: fermented meats), Silver nitrate, Trinitrotoluene