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Table 1 Comparative bleeding rates for warfarin versus dabigatran, rivaroxaban, apixaban and edoxaban [7]

From: The impact of prothrombin complex concentrates when treating DOAC-associated bleeding: a review

  RE-LY [5] ROCKET-AF [6] ARISTOTLE [136] ENGAGE-AF TIMI [4]
Dabigatran 150 mg (n = 6076) Dabigatran 110 mg (n = 6015) Warfarin (n = 6022) Rivaroxaban (n = 7111) Warfarin (n = 7125) Apixaban (n = 9088) Warfarin (n = 9052) Edoxaban 60 mg (n = 7012) Edoxaban 30 mg (n = 7002) Warfarin (n = 7012)
Major bleeding rate (%) per year 3.11 2.71 3.36 3.6 3.4 2.13 3.09 2.75 1.61 3.43
Hazard ratio vs warfarin 0.93 (0.81–1.07); p = 0.31 0.80 (0.69–0.93); p = 0.003 / 1.04 (0.90–1.20); p = 0.58 / 0.69 (0.60–0.80); p < 0.001 / 0.80 (0.71–0.91); p < 0.001 0.47 (0.41–0.55); p < 0.001 /