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Table 1 Published cases of cannabinoid hyperemesis syndrome in pregnant women

From: Cannabinoid hyperemesis syndrome in the pregnant patient: clinical case and literature review

Number

Reference

Age, y

Obstetric status

Gestation period, weeks; days

Nausea and vomiting + Cannabis use + hot shower/bath

Shower effect

Usual consumption (how long/how many times per week)

Antiemetic/effect

Other examinations

Delivery

1

Schmid et al., 2011 [8]

26

G2P0A1

10; ?/?

All 3

Beneficial

13 years/daily

Metoclopramide

Chlorazine

Dexamethasone

Ondansetron

Vitamin B6/ineffective

Urinary and blood tests

Uncomplicated

2

Alaniz et al., 2015 [9]

28

G5P3A1

30; 5/7

All 3

Beneficial

12 years/daily

Unspecified molecule/ineffective

Blood test + cerebral and abdominal magnetic resonance imaging

NICU for hypoxia.

Hospital discharge on the second day in good condition

3

Andrews et al., 2015 [10]

24

G5P2A2

26; 2/7

All 3

Beneficial

8 years/several times per week

Treatment incompletely specified. Metoclopramide effectiveness associated with stopping cannabis use and a prescription of hot showers

Blood test Abdominal x-ray

Abdominal and pelvic CT scan

37 wks

2270 g

APGAR 9/9; No complications described

4

Manning Meurer et al., 2018 [11]

21

G1P0A0

6; ?/?

Shower/bath not described

?

?

Treatment: unspecified molecule/no description of efficacy

Blood test digestive endoscopy

Induced at 36 wks 6/7 for pre-eclampsia.

2430 g

Fetal deceleration

Shoulder dystocia

APGAR 1/5

19 days in NICU

Baby intracranial hemorrhage and spontaneous resorption.

At 10 months of life, normal baby evolution

5

Kim et al., 2018 [12]

20

G7P0A6

14; 3/7

All 3

Beneficial

?

Ondansetron

Famotidine

Metoclopramide

Ondansetron per os

Promethazine IR

All ineffective

Blood test

40 wks 1/7

3190 g

APGAR 8/9

No complications described

6

This case

29

G1P0A0

29

All 3

Beneficial

6 years/daily

Metoclopramide/no effect

Blood test

Abdominal and pelvic ultrasound

39 wks 6/7

2650 g

No complications. Hospital discharge on the third day in good condition

  1. ? indicates no data available, NICU neonatal intensive care unit, y years, wks weeks, g grams