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Table 1 Summary of included studies

From: Use of sodium bicarbonate in out-of-hospital cardiac arrest: a systematic review and meta-analysis

Author, year Country Study design Interventions, No. of patients Mean age, SD or range (BS vs. control) Sex, male (BS vs. control) Study duration Main findings
Ahn et al. 2018 [21] Korea RCT SB (n=25) vs. placebo (n=25) 65.5 (16.4)/64.1 (15.4) 18/21 January–December 2015 No difference between SB and placebo in sustained ROSC and survival
Chen et al. 2018 [23] Taiwan Population-based cohort study SB (n=1885) vs. control (n=3704) Older than 18 years 1140/2379 1997–2012 Positive association between SB and survival
Kawano et al. 2017 [24] Columbia Population-based observational study SB (n=5165) vs. control (n=8700) 65 (52–77)/68 (56–80) 3682/5779 2005–2016 SB had less survival
Chung et al. 2015 [25] China Retrospective observational study SB (n=74) vs. control (n=415) 65.9 (22.7)/72.8 (19.9) 52/237 March–December 2013 SB had a higher percentage of ROSC and survival
Weng et al. 2013 [26] Taiwan Retrospective cohort SB (n=30) vs. control (n=62) 65/70.5 19/47 January 1–December 2009 SB did not improve rate of ROSC in prolonged (> 15 min) cardiac arrest
Vukmir and Katz 2006 [15] USA RCT SB (n=420) vs. control (n=372) 67.37 (15.29)/67.16 (14.96)   1994–1998 Overall survival 13.9% (110/792), no difference between groups
Dybvik et al. 1995 [14] Norway RCT SB (n=245) vs. saline (n=257) 236/266 - 1987–1994 SB therapy had no effect on outcome
Stiell et al. 1995 [28] Canada Observational cohort study BS vs. atropine, Ca, lidocaine, bretylium, procainamide, n=529 19 to 98 - 2 years Logistic regression did not show association between SB and survival
Aufderheide et al. 1992 [16] USA Retrospective chart review SB (n=215) vs. No SB (n=58) 67 (13)/65 (12) 143/39 1982—1984. No association between SB and survival
Weaver et al. 1990 [22] USA RCT SB (n= 224), lidocaine (n=106), epi (n=93) 65.6 (12.6)/67.5 (13.2)/66.3 (1.3) 177/89/77 1983–1985 Higher survival with SB infusion
Kim et al. 2016 [13] Korea Observational study SB (n=771) 68 (52–77) 375 2008–2013 SB was associated with increased ROSC.
Bar-Joseph et al. 2005 [12] USA Retrospective study SB (n=2122) - - 1990—1992 Earlier and more frequent use of SB associated with higher ROSC
Bar-Joseph et al. 2002 [27] USA Retrospective study SB (n=2915) - 1955 1990–1992. SB given in 54% of cases, use increased with ACLS duration
Delooz and Lewi 1989 [29] Belgium Retrospective data analysis SB - - - SB > 1 mEq/kg associated with poor outcome
  1. RCT randomized controlled trial, SB sodium bicarbonate, ROSC return of spontaneous circulation, CPR cardiopulmonary resuscitation, ACLS advanced cardiac life support