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Table 1 Baseline characteristics among septic patients defined by SOFA or SIRS criteria

From: Microbiological findings in emergency department patients with sepsis identified by the Sepsis-3 criteria: a single-center prospective population-based cohort study

  SOFA(n = 466) SIRS(n = 398) Difference(95% CI)
Female sex, n (%) 195(41.9) 217(54.5) 12.6(6.0–19.2)
Age, median, years (IQR) 74.1(65–83) 71.2(56–80) 4.7(2.6–6.8)
Charlson Comorbidity Index, n    
 0 109(23.4) 125(31.4) 8.0(2.0–14.0)
 1–2 232(49.8) 195(49.0) 0.8(÷5.9–7.5)
 3+ 125(26.8) 78(19.6) 7.2(1.6–12.8)
Previously admitted with sepsis, n (%) 153(32.8) 110(27.6) 5.2(÷0.9–11.3)
Length of stay, median, days (IQR) 6.7(4.0–10.6) 4.3(2.7–7.0) 1.9(1.3–2.4)
Vital signs on admission, median (IQR)    
 Severity of disease    
  Total SOFA score 3(2–4) 0(0–1)
  Systolic blood pressure, mmHga (IQR) 122(106–145) 135(122–150) 12(9–15)
   ≤ 90 mmHg, n(%) 37(7.9) 2 (0.5) 7.4(4.9–10.0)
  Respiratory rate, breaths/min (IQR) 21(18–26) 21 (18–25) 0
  Heart rate, beats/min (IQR) 95(81–112) 102(93–112) 7(4–10)
  Peripheral oxygen saturation, %(IQR) 95(93–97) 96(94–98) 1(1–2)
  Core temperature, °Cb (IQR) 37.7(36.8–38.5) 38.3(37.5–38.8) 0.5(0.3–0.7)
  Glasgow Coma Scale < 15, n (%) 122(30.4) 30(7.5) 22.9(18.0–27.8)
Laboratory variables, median (IQR)    
 C-reactive protein (mg/L) 94(36–167) 104(35–174) 3(÷13–7)
 White blood cell count, (× 109/L) 12.4(9.0–17.5) 13.8(10.5–17.3) 1.2(0.5–2.0)
 Creatinine (μmol/L) 111(73–168) 74(61–92) 32(25–39)
 Bilirubin (μmol/L) 11(7–17) 9(6–13) 2(1–2)
 Platelet count (× 109/L) 206(144–280) 256(207–324) 57(45–70)
 Lactate (mmol/L)c 1.4(0.9–2.2) 1.0(0.7–1.7) 0.3(0.2–0.4)
 Glucose (mmol/L) 7.3(6.1–8.9) 6.7(6.0–8.1) 0.4(0.1–0.6)
Admission to ICU, n (%) 73(15.7) 20(5.0) 10.7(6.7–14.6)
 Vasopressor therapy, n (%) 14(3.0) 3(0.8) 2.2(0.4–4.0)
 Ventilation therapy, n (%) 28(6.0) 7(1.8) 4.2(1.7–6.7)
 Dialysis treatment, n (%) 3(0.6) 1(0.3) 0.3(÷0.5–1.2)
  1. CI confidence interval, ICU intensive care unit, IQR interquartile range, SOFA Sequential Organ Failure Assessment, SIRS systemic inflammatory response syndrome,
  2. a9 missing (7 and 2 in the SOFA and SIRS group, respectively)
  3. b17 missing (10 and 7 in the SOFA and SIRS group, respectively)
  4. c405 missing (175 and 230 in the SOFA and SIRS group, respectively)