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Table 1 Patient data at the time of presentation to the Emergency Department

From: COVID-19 masquerading as a non-convulsive status epilepticus

Value (normal range)

Venous blood puncture

 

Hemoglobin, g/dL (12.0–16.0)

13.4

White cell count, ×109/L (3.5–11)

8.07

Neutrophil count, × 109/L (1.50–6.70)

6.44

Lymphocyte count, × 109/L (1.20–3.50)

0.95

Platelet count, ×109/L (150–440)

202

C-Reactive Protein, mg/L (<5.0)

56.3

D-Dimer, ng/mL (0–500)

7393

PT, seconds (9.9–11.8)

11.8

APTT, seconds (21.6–28.7)

24

Anti-Factor Xa activity, U anti-Xa/mL

1.06

Sodium, mmol/L (136–145)

130

Potassium, mmol/L (3.4–4.4)

3.8

Chloride, mmol/L (98–107)

89

Bicarbonate, mmol/L (23–29)

27

Urea, mg/dL (17–48)

60

Creatinine, mg/dL (0.50–0.90)

1.73

Serum glucose, mg/dL (70–100)

142

Alanine transaminase, U/L (<33)

19

Creatine kinase, U/L (26–192)

2376

Myoglobin, mcg/L (<58)

6063

Lactate, mmol/L (0.7–2.0)

1.6

Ammonia, mcg/dL (18.7–86.9)

21

Bioactive monomeric prolactin, mcg/L (3.5–18.0)

29.4

TSH, mU/L (0.27–4.20)

3.78

Peripheral venous blood culture set (2 independent sets)

Negative

Arterial blood puncture at ED admission (FiO2 100%)

 

pH (7.35–7.45)

7.47

pCO2, mm Hg (32–45)

35

pO2, mm Hg (75–104)

234

P/F ratio (>300)

234

Saturation O2, % (95–98)

100

Carboxyhemoglobin, % (<1.0)

0.9

Methemoglobin, % (<0.5)

0.7

Arterial blood puncture at ICU admission (FiO2 40%)

 

pH (7.35–7.45)

7.48

pCO2, mm Hg (32–45)

35

pO2, mm Hg (75–104)

102

P/F ratio (>300)

255

Saturation O2, % (95–98)

98

CSF examination

 

CSF macroscopic examination

Crystal clear

CSF opening pressure, cmH20

-

CSF red cell, × 109/L (0–5)

0.1

CSF white cell, × 109/L (0–5)

2.8

CSF glucose, mg/dL (45–80)

75.8

CSF protein, g/L (0.15–0.45)

0.44

CSF oligoclonal bands

-

CSF lactate, mmol/L (1.11–2.44)

3.76

CSF PCR for SARS-CoV2

Negative

CSF FilmArray Meningitis/Encephalitis Panel*

Negative

CSF PCR for Herpes Simplex 1

Negative

CSF bacterial and fungal culture

Negative

CSF antinuclear antibodies

Negative

Antibodies against NMDAR, LGi1, CASPR2, GABA-B1/B2, DPPX, AMPA1/2 in serum, and CSF

Negative

Paraneoplastic anti-neuronal antibodies in serum and CSF

Negative

Urine analysis

 

Leucocytes/μL (<10)

26

Erythrocytes/μL (<12)

26

Epithelial cells

Absent

Hyalin casts

+++

Crystals

Absent

Bacteria

+

Fungi

Absent

Urine culture set

Negative

  1. PT prothrombin time, APTT activated partial prothrombin time, TSH thyroid stimulating hormone, CSF cerebrospinal fluid, NMDAR N-methyl-d-aspartate receptor, LGi1 leucine-rich glioma inactivated 1, CASPR2 contactin-associated protein 2, GABA-B γ-Aminobutyric acid-B receptor, DPPX dipeptidyl aminopeptidase-like protein 6, AMPA1/2 GluR1 and GluR2 subunits of the AMPA receptor; Paraneoplastic antibodies included anti-Hu, anti-Yo, anti-Ri, and anti-amphiphysin
  2. *Escherichia coli K1, Haemophilus influenzae, Listeria monocytogenes, Neisseria meningitidis, Streptococcus pneumoniae, Streptococcus agalactiae, cytomegalovirus, enterovirus, herpes simplex virus 1 and 2, human herpesvirus 6, human parechovirus, varicella-zoster virus, and Cryptococcus neoformans/Cryptococcus gattii