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Table 1 Characteristics of appropriate antibiotics group (time < 60 min, spectrum, dose) and inappropriate antibiotics group

From: Effect of appropriate dose, spectrum, and timing of antibiotics on 28-day mortality in patients with sepsis in the emergency department

Characteristics Appropriate antibiotics N=323 Inappropriate antibiotics N=270 P value
Age (years), mean ± SD 70.7±16.91 67±18.02 0.62
Gender
 Male, n (%) 151 (46.7%) 115 (42.6%) 0.31
Underlying conditions, n (%)    
 Hypertension 183 (56.7%) 140 (51.9%) 0.24
 Diabetes mellitus 115 (35.6%) 100 (37%) 0.72
 Chronic kidney disease 86 (26.6%) 69 (25.6%) 0.77
 Heart disease 88 (27.2%) 50 (18.5%) 0.01
 Liver disease 35 (10.8%) 25 (9.3%) 0.53
 Immunocompromised 111 (34.4%) 101 (37.4%) 0.44
Vital signs at triage, mean ± SD
 Systolic BP (mmHg) 133.18±32.25 129.26±29.25 0.125
 Diastolic BP (mmHg) 71.84±15.58 70.86±13.77 0.42
 Heart rate (bpm) 108.05±23.21 107.38±20 0.72
 Body temperature (°C) 38.28±1.1 38.32±0.99 0.57
 Respiratory rate (bpm) 24.78±5.1 23.07±4.38 < 0.001
 Oxygen saturation (%) 94.38±7.5 97.07±2.98 < 0.001
Laboratory results, mean ± SD
 White blood cell counta (× 103) 10.0 (6.7, 13.7) 9.95 (6.8, 13.2) 0.95
 Platelet counta (×103) 207.0 (147, 280) 211.5 (154, 284) 0.90
 Serum creatininea 0.98 (0.72, 1.48) 0.93 (0.68, 1.39) 0.50
 Initial serum lactate (mmol/L), mean ± SD 2.54±1.61 2.41±1.61 0.36
qSOFA scorea 1 (1,1) 1 (0,1) < 0.001
SOFA scorea 1 (0,3) 1 (0,3) 0.24
Severity    
 Sepsis, n (%) 295 (91.3%) 245 (90.7%) 0.80
 Septic shock, n (%) 28 (8.7%) 25 (9.3%)  
 Time triage to antibioticsa (minutes) 39 (30, 50) 73 (55, 101) < 0.001
 Fluids in first houra (mL) 80 (80, 400) 100 (80, 400) < 0.001
  1. aMedian (interquartile range); rank-sum test
  2. SD standard deviation, BP blood pressure, qSOFA quick Sequential Organ Failure Assessment score