Effect of appropriate dose, spectrum, and timing of antibiotics on 28-day mortality in patients with sepsis in the emergency department

Table 3 Comparison of outcomes between spectrum in appropriate antibiotics and inappropriate spectrum antibiotics groups

	Appropriate antibiotics spectrum, N=489	Inappropriate antibiotics spectrum, N=104	Adjusted odds ratio^a Adjusted coefficient^b: Appropriate antibiotics	P value
28-day mortality, n (%)	14 (2.9%)	9 (8.78%)	0.38 (0.15, 0.99) ^a	0.047
In-hospital mortality, n (%)	21 (4.3%)	15 (14.4%)	0.28 (0.13, 0.61) ^a	0.001
28-day ventilator- free days, mean ± SD	26.77±4.46	23.75±8.73	0.06** (0.01, 0.11) ^b	0.01
28-day hospital-free days, mean ± SD	21.27±8.08	16.90±10.48	0.10** (− 0.00, 0.21) ^b	0.06

^aAdjusted odds ratio (95% confidence interval): qSOFA, respiratory rate, oxygen saturation
^bApply log transformation for fitting model to normal distribution before adjusted coefficient (mean difference): qSOFA, respiratory rate, oxygen saturation. After we did a log transform, 16 data of 28-day ventilator free day and 57 data of 28-day hospital free day were missing because log [0] transformed to infinities. We had completed case analysis as 577 patients for 28-day ventilator free day and 536 patients 28-day hospital free day outcomes
SD standard deviation, qSOFA quick Sequential Organ Failure Assessment

ISSN: 1865-1380