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Table 4 Comparison of primary and secondary outcomes between appropriate antibiotics and inappropriate antibiotics groups in subgroup patients who had SOFA ≥ 2

From: Effect of appropriate dose, spectrum, and timing of antibiotics on 28-day mortality in patients with sepsis in the emergency department

Outcomes Appropriate antibiotics
N=155
Inappropriate antibiotics
N=115
Adjusted odds ratioa
Adjusted coefficientb:
Appropriate antibiotics
P value
Primary outcomes     
 28-day mortality, n (%) 9 (5.81%) 9 (7.83%) 0.60 (0.19, 1.77) a 0.35
 In-hospital mortality, n (%) 59 (9.68%) 14 (12.17%) 0.68 (0.29, 1.60) a 0.38
 28-day ventilator- free days, mean ± SD 25.35±6.70 25.36±7.04 − 0.01 (− 0.09, 0.06) b 0.71
 28-day hospital-free days, mean ± SD 18.96±8.94 17.95±9.84 0.08 (− 0.05, 0.22) b 0.21
  1. aAdjusted odds ratio (95% confidence interval): qSOFA, respiratory rate, oxygen saturation
  2. bApply log transformation for the fitting model to normal distribution before Adjusted coefficient (mean difference): qSOFA, respiratory rate, oxygen saturation. After we did a log transform, 12 data of 28-day ventilator-free day and 36 data of 28-day hospital free day were missing because log [0] transformed to infinities. We had completed case analysis as 258 patients for 28-day ventilator-free day and 234 patients 28-day hospital-free day outcomes
  3. SD standard deviation, qSOFA quick Sequential Organ Failure Assessment, SOFA Sequential Organ Failure Assessment