Effect of appropriate dose, spectrum, and timing of antibiotics on 28-day mortality in patients with sepsis in the emergency department

Table 4 Comparison of primary and secondary outcomes between appropriate antibiotics and inappropriate antibiotics groups in subgroup patients who had SOFA ≥ 2

Outcomes	Appropriate antibiotics N=155	Inappropriate antibiotics N=115	Adjusted odds ratio^a Adjusted coefficient^b: Appropriate antibiotics	P value
Primary outcomes
28-day mortality, n (%)	9 (5.81%)	9 (7.83%)	0.60 (0.19, 1.77) ^a	0.35
In-hospital mortality, n (%)	59 (9.68%)	14 (12.17%)	0.68 (0.29, 1.60) ^a	0.38
28-day ventilator- free days, mean ± SD	25.35±6.70	25.36±7.04	− 0.01 (− 0.09, 0.06) ^b	0.71
28-day hospital-free days, mean ± SD	18.96±8.94	17.95±9.84	0.08 (− 0.05, 0.22) ^b	0.21

^aAdjusted odds ratio (95% confidence interval): qSOFA, respiratory rate, oxygen saturation
^bApply log transformation for the fitting model to normal distribution before Adjusted coefficient (mean difference): qSOFA, respiratory rate, oxygen saturation. After we did a log transform, 12 data of 28-day ventilator-free day and 36 data of 28-day hospital free day were missing because log [0] transformed to infinities. We had completed case analysis as 258 patients for 28-day ventilator-free day and 234 patients 28-day hospital-free day outcomes
SD standard deviation, qSOFA quick Sequential Organ Failure Assessment, SOFA Sequential Organ Failure Assessment

ISSN: 1865-1380