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Table 5 Characteristics of infection source among survivors and non-survivors at 28 days

From: Effect of appropriate dose, spectrum, and timing of antibiotics on 28-day mortality in patients with sepsis in the emergency department

Characteristics, n (%) 28-day survival, N=570 28-day mortality, N=23 P value
Source    0.64
 Pneumonia 195 (34.2%) 9 (31.9%)
 Urinary tract 212 (37.2%) 5 (21.7%)
 Gastrointestinal 55 (9.6%) 5 (21.7%)
 Soft tissue, bone, and joints 31 (5.4%) 2 (8.7%)
 Septicemia/catheter-relate/FN 58 (10.2%) 2 (8.7%)
 Hepatobiliary 10 (1.8%) 0 (0%)
 CNS 2 (0.4%) 0 (0%)
 Unknown 6 (1.1%) 0 (0%)
Source, positive culture 237(41.6%) 12 (52.2%) 0.31
Pathogen in positive culture    0.53
Escherichia coli 45 (7.9%) 3 (13%)
E. coli (ESBL) 58 (10.2%) 2 (8.7%)
Klebsiella 21 (3.7%) 0 (0%)
Klebsiella (ESBL) 9 (1.36%) 2 (8.7%)
Pseudomonas aeruginosa 22 (3.9%) 0 (0%)
Staphylococcus spp. 12 (2.1%) 1 (4.3%)
Streptococcus spp. 7 (1.2%) 0 (0%)
 Other 46 (8.1%) 5 (21.7%)
 No growth 350 (61.4%) 10 (4.5%)
Infection source sensitivity to first dose antibiotic 496 (87%) 15 (65.2%) < 0.01
Hemoculture positive 85 (14.9%) 4 (17.4%) 0.74
Pathogen in positive hemoculture    0.25
Escherichia coli 16 (2.8%) 0 (0%)
E. coli (ESBL) 16 (2.8%) 1 (4.3%)
Klebsiella 3 (0.5%) 0 (0%)
Klebsiella (ESBL) 1 (0.2%) 0 (0%)
Pseudomonas aeruginosa 6 (1.1%) 0 (0%)
Staphylococcus spp. 22 (3.9%) 0 (0%)
Streptococcus spp. 4 (0.7%) 0 (0%)
 Other 15 (2.6%) 3 (13%)
 No growth 487 (85.4%) 19 (82.6%)
Hemoculture sensitivity to first antibiotic 541 (95.1%) 20 (87%) 0.09
Appropriate time to antibiotics (within 60 min) 375 (65.8%) 20 (87.0%) 0.04
Appropriate spectrum of antibiotics 475 (83.3%) 14 (60.9%) 0.005
Appropriate dose of antibiotics 568 (99.6%) 23 (100%) 1.00 a
Appropriate antibiotics (time <60 min + spectrum + dose) 311 (54.6%) 12 (52.5%) 0.82
  1. aFisher’s exact test