Table 5 Characteristics of infection source among survivors and non-survivors at 28 days
Characteristics, n (%) | 28-day survival, N=570 | 28-day mortality, N=23 | P value |
|---|---|---|---|
Source | 0.64 | ||
Pneumonia | 195 (34.2%) | 9 (31.9%) | |
Urinary tract | 212 (37.2%) | 5 (21.7%) | |
Gastrointestinal | 55 (9.6%) | 5 (21.7%) | |
Soft tissue, bone, and joints | 31 (5.4%) | 2 (8.7%) | |
Septicemia/catheter-relate/FN | 58 (10.2%) | 2 (8.7%) | |
Hepatobiliary | 10 (1.8%) | 0 (0%) | |
CNS | 2 (0.4%) | 0 (0%) | |
Unknown | 6 (1.1%) | 0 (0%) | |
Source, positive culture | 237(41.6%) | 12 (52.2%) | 0.31 |
Pathogen in positive culture | 0.53 | ||
Escherichia coli | 45 (7.9%) | 3 (13%) | |
E. coli (ESBL) | 58 (10.2%) | 2 (8.7%) | |
Klebsiella | 21 (3.7%) | 0 (0%) | |
Klebsiella (ESBL) | 9 (1.36%) | 2 (8.7%) | |
Pseudomonas aeruginosa | 22 (3.9%) | 0 (0%) | |
Staphylococcus spp. | 12 (2.1%) | 1 (4.3%) | |
Streptococcus spp. | 7 (1.2%) | 0 (0%) | |
Other | 46 (8.1%) | 5 (21.7%) | |
No growth | 350 (61.4%) | 10 (4.5%) | |
Infection source sensitivity to first dose antibiotic | 496 (87%) | 15 (65.2%) | < 0.01 |
Hemoculture positive | 85 (14.9%) | 4 (17.4%) | 0.74 |
Pathogen in positive hemoculture | 0.25 | ||
Escherichia coli | 16 (2.8%) | 0 (0%) | |
E. coli (ESBL) | 16 (2.8%) | 1 (4.3%) | |
Klebsiella | 3 (0.5%) | 0 (0%) | |
Klebsiella (ESBL) | 1 (0.2%) | 0 (0%) | |
Pseudomonas aeruginosa | 6 (1.1%) | 0 (0%) | |
Staphylococcus spp. | 22 (3.9%) | 0 (0%) | |
Streptococcus spp. | 4 (0.7%) | 0 (0%) | |
Other | 15 (2.6%) | 3 (13%) | |
No growth | 487 (85.4%) | 19 (82.6%) | |
Hemoculture sensitivity to first antibiotic | 541 (95.1%) | 20 (87%) | 0.09 |
Appropriate time to antibiotics (within 60 min) | 375 (65.8%) | 20 (87.0%) | 0.04 |
Appropriate spectrum of antibiotics | 475 (83.3%) | 14 (60.9%) | 0.005 |
Appropriate dose of antibiotics | 568 (99.6%) | 23 (100%) | 1.00 a |
Appropriate antibiotics (time <60 min + spectrum + dose) | 311 (54.6%) | 12 (52.5%) | 0.82 |