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Table 3 Bivariate analysis for invasive mechanical ventilation

From: Clinical characteristics and mortality associated with COVID-19 at high altitude: a cohort of 5161 patients in Bogotá, Colombia

Variable Overall
(n = 5161)
No requirement of invasive mechanical ventilation (n = 4263) Missing (n) Invasive mechanical ventilation (n = 898) Missing (n) p-value
Demographic
 Age median (IQR) 66 (53–77) 65 (51–78) 0 68 (59–75) 0 < 0.01*
 Days of ICU (IQR)   4 (2–7) 3891 11 (7–18) 60 < 0.01*
 Days of hospital stay (IQR) 8 (4–13) 7 (3–11) 0 16 (10–25) 0 < 0.01*
 Body mass index median (IQ) 26.34 (23.4–29.38) 26.1 (23.4–29.2) 3 27.3 (24.3–31.1) 0 < 0.01*
Sex
 Female 2340 (45.34%) 2036 (87%) - 304 (12%) - < 0.01*
 Male 2821 (54.65%) 2227 (78%) - 594 (21%) - < 0.01*
Management site
 Outpatient 854 (16.54%) 854 (100%) - 0 (0%) - -
 Inpatient 2970 (57.54%) 2962 (99%) - 8 (0.002%) - -
 Emergency 114 (2.20%) 75 (65%) - 39 (34%) - -
 ICU 1223 (23.69%) 372 (30%) - 851 (70%) - -
Outcome
 Alive 3856 (75%) 3571 (92%) - 285 (0.7%) - < 0.01*
 Dead 1305 (25%) 692 (53%) - 613 (46%) - < 0.01*
Comorbidities
 Hypertension 1171 (22.68%) 935 (79%) - 236 (20%) - < 0.01*
 HIV 9 (0.17%) 8 (88%) - 1 (11%) - -
 COPD 290 (5.61%) 232 (8%) - 58 (2%) - -
 Diabetes mellitus 256 (4.96%) 193 (0.37%) - 63 (0.12%) - < 0.01*
Laboratory values (IQR)
 Leukocyte blood count 7,985 (0.2–262.9) 7.7 (5.72–10.49) 432 9.27 (6.7–12.95) 7 < 0.01*
 Neutrophil-lymphocyte ratio 6,0303 (3,4258–10,7008) 5,436 (3,168–9,674) 434 9,378 (5,399–16,548) 8 < 0.01*
 Haematocrit 43.4 (39.2–47) 43.3 (39.2–46.9) 427 43.9 (39.4–47.5) 7 < 0.01*
 Haemoglobin 14.5 (13–15.8) 14.4 (13–15.7) 426 14.7 (13.1–16) 7 < 0.01*
 LDH 337 (255–445) 317 (243–407) 725 453.5 (341–590) 40 < 0.01*
 D-Dimer 950 (540–1802.25) 920 (523.2–1711.5) 937 1093 (600–2028) 76 < 0.01*
 Procalcitonin 0.31 (0.12–1.01) 0.2 (0.09–0.58) 3347 0.58 (0.23–1.92) 245 < 0.01*
 Ferritin 881 (478–1612.5) 816 (462–1538) 4002 1244 (79.7–1925.7) 832 < 0.01*
Oxygenation indices (IQR)
 S/F ratio at admission 339.28 (310.71–423.80) 342,857 (321.4–428.57) 163 300 (161–347) 3 < 0.01*
 S/F ratio at 48 h 325 (254.28–341.52) 328.57 (307.1–346.4) 777 202.2(145–317) 29 < 0.01*
 P/F ratio at admission 233,3854 (180,9524–274,6429) 243.21 (200.4–281) 777 171.4 (98.2–231.4) 29 < 0.01*
 S/F ratio at ICU admission   278.1 (156.6–332.1) 3942 150 (96–192) 69 < 0.01*
 P/F ratio at ICU admission   154.5 (91–244.9) 3973 112.6 (79.9–150.5) 76 < 0.01*
  1. ICU intensive care unit, COPD chronic obstructive pulmonary disease, HIV human immunodeficiency virus, LDH lactate dehydrogenase, S/F oxygen saturation to fraction inspired oxygen, P/F partial pressure of oxygen to fraction inspired oxygen
  2. *P-value refers to statistically significant result