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Table 3 Results of the univariate logistic regression analysis

From: Factors associated with non-invasive positive pressure ventilation failure in a COVID-19 intermediate care unit

 

OR

(95% CI)

p value

Age

1.058

(1.028–1.089)

< 0.001

Frailty score

2.479

(1.460–4.211)

0.001

Highest creatinine

1.590

(1.162–2.177)

0.004

Highest LDH

1.004

(1.002–1.006)

< 0.001

Highest total bilirubin

2.330

(1.15–4.721)

0.019

Highest CRP

1.114

(1.068–1.161)

< 0.001

Highest procalcitonin

1.328

(1.073–1.643)

0.009

Highest ferritin

1.000

(1.000–1.000)

0.010

Highest leukocyte count

1.111

(1.047–1.178)

< 0.001

Highest ESR

1.018

(1.001–1.036)

0.041

Highest D-Dimer

1.000

(1.000–1.000)

0.112

Lowest lymphocyte count

1.089

(0.912–1.300)

0.347

Lowest platelet count

0.988

(0.982–0.995)

< 0.001

PaO2 after starting NIPPV

0.992

(0.985–0.999)

0.026

SpO2 after starting NIPPV

0.741

(0.626–0.876)

< 0.001

PaO2/FiO2 ratio before starting NIPPV

0.997

(0.992–1.002)

0.258

PaO2/FiO2 ratio after starting NIPPV

0.987

(0.982–0.993)

< 0.001

Highest IPAP

1.380

(1.182–1.612)

< 0.001

Highest EPAP/CPAP

1.966

(1.469–2.630)

< 0.001

Highest tidal volume

1.002

(1.001–1.004)

0.006

Highest respiratory rate

1.192

(1.115–1.274)

< 0.001

Steroids

0.000

(0.000–?)

0.999

Remdesivir

0.235

(0.121–0.458)

< 0.001

Antibiotics

3.275

(1.705–6.291)

< 0.001

Morphine

17.318

(6.236–48.088)

< 0.001

Sedationa

5.891

(2.754–12.602)

< 0.001

Adherence to prone positioning

0.084

(0.033–0.218)

< 0.001

  1. CPAP continuous positive airway pressure, CRP C-reactive protein, EPAP expiratory positive airway pressure, FiO2 fraction of inspired oxygen, IPAP inspiratory positive airway pressure, LDH lactate dehydrogenase, NIPPV non-invasive positive pressure ventilation, PaO2 partial pressure of oxygen, SpO2 oxygen saturation
  2. aOther than morphine (benzodiazepines. antipsychotics)