Table 1 Drug interactions implicated in serotonin syndrome
From: The serotonin syndrome—the need for physician’s awareness
Antidepressants: | Monoamine oxidase inhibitors (MAOIs), TCAs, SSRIs, bupropion |
Opioids: | Tramadol, pethidine, meperidine |
CNS stimulants: | Phentermine, diethylpropion, amphetamines, methylphenidate, methamphetamine, cocaine |
5-HT1 agonists: | Triptans |
Phenethylamines: | MDMA, amphetamines, methylphenidate, methamphetamine |
Indoles: | Psilocybin, LSD |
Others: | Tryptophan, montelukast, buspirone, lithium, linezolid, dextromethorphan, 5-Hydroxytryptophan, chlorpheniramine |
Herbs: | St John’s wort, yohimbe |