Table 1 Univariate analysis of risk factors for in-hospital mortality
From: The duration of SIRS before organ failure is a significant prognostic factor of sepsis
Prognostic factor | Non-survivors (n = 41) | Survivors (n = 69) | P value |
|---|---|---|---|
Gender (men) | 30 (73.2) | 42 (60.9) | 0.190 |
Age | 69.3 ± 1.7 | 59.7 ± 1.8 | 0.001 |
APACHE II score | 26.6 ± 0.1 | 20.3 ± 0.8 | < 0.001 |
SOFA score | 10.1 ± 0.7 | 8.3 ± 0.4 | 0.040 |
DIC score | 4.5 ± 0.32 | 4.37 ± 0.25 | 0.776 |
Shock | 24 (58.5) | 35 (50.7) | 0.427 |
Underlying disease | 27 (58.5) | 37 (53.6) | 0.209 |
Chronic cardiac insufficiency | 3 (11.1) | 3 (7.9) | |
Diabetes mellitus | 4 (14.8) | 9 (23.7) | |
Hepatic cirrhosis | 6 (22.2) | 6 (15.8) | |
Immunosuppression | 8 (29.6) | 10 (26.3) | |
Neoplasm | 4 (14.8) | 5 (13.2) | |
Chronic renal insufficiency | 1 (3.7) | 1 (2.6) | |
Chronic pulmonary insufficiency | 1 (3.7) | 3 (7.9) | |
Localization of infection | |||
Abdomen | 16 (39.0) | 34 (49.3) | |
Lung | 19 (46.3) | 19 (27.5) | 0.045 |
Soft tissue | 5 (12.2) | 10 (14.5) | |
Others | 1 (2.4) | 6 (8.7) | |
From the general ward in our hospital | 22 (53.7) | 37 (53.6) | 0.997 |
Post surgery | 8 (19.5) | 21 (30.4) | 0.209 |
First antibiotic sensitivity | 14 / 27 (51.9) | 22 / 50 (44.0) | 0.510 |
Time lag between first detection of SIRS and administration of antibiotics | 12.8 ± 3.5 | 21.5 ± 6.4 | 0.125 |
GCS | 11.0 ± 0.6 | 11.6 ± 0.4 | 0.432 |
BUN (mg/dl) | 43.3 ± 4.2 | 32.7 ± 2.7 | 0.012 |
Cr (mg/dl) | 2.12 ± 0.21 | 1.64 ± 0.17 | 0.051 |
T-bilirubin (mg/dl) | 3.44 ± 0.77 | 2.70 ± 0.57 | 0.175 |
AT III (%) | 47.6 ± 3.1 | 63.1 ± 2.7 | 0.001 |
Fibrinogen (mg/dl) | 412 ± 33 | 463 ± 18 | 0.295 |
Platelets (×10 4/μl) | 11.6 ± 1.5 | 13.6 ± 1.6 | 0.619 |
CRP (mg/dl) | 17.4 ± 1.4 | 16.6 ± 1.1 | 0.625 |
Ht (%) | 31.0 ± 1.2 | 29.6 ± 0.7 | 0.422 |
DSOF (h) | 58.8 ± 16.5 | 74.7 ± 9.6 | 0.015 |
DSOF (≤ 24 h) | 26 (63.4) | 24 (34.8) | 0.004 |
DSOF (≤ 48 h) | 30 (73.2) | 38 (55.1) | 0.059 |