Table 2 The diagnostic accuracy of CSF lactate for bacterial meningitis by cutoff point
From: Cerebrospinal fluid lactate level as a diagnostic biomarker for bacterial meningitis in children
CSF lactate (mmol/l) | n = 451 | Sensitivity | Specificity | Negative predictive value (NPV) |
|---|---|---|---|---|
n(%) | n (%) (95% CI) | n(%) (95% CI) | n% (95% CI) | |
≥1.0 mmol/l | 442 (98) | 100 (91.2-100) | 2.8 (1.3-5.2) | 100 (66.4-100) |
≥1.5 mmol/l | 388 (86) | 100 (91.2-100) | 25.2 (20.5-30.2) | 100 (95.6-100) |
≥2.0 mmol/l | 246 (55) | 97.5 (86.8-99.9) | 55.2 (49.6-60.7) | 99.4 (97.0-100) |
≥2.5 mmol/l | 102 (23) | 95.0 (83.1-99.4) | 85.6 (81.3-89.2) | 99.3 (97.5-99.9) |
≥3.0 mmol/l | 56 (12) | 95.0 (83.1-99.4) | 93.6 (90.3-96.0) | 99.3 (97.7-99.9) |
≥3.5 mmol/l | 47 (10) | 90.0 (76.3-97.2) | 96 (93.3-97.9) | 98.7 (96.8-99.7) |
≥4.0 mmol/l | 34 (7.5) | 82.5 (67.2-92.7) | 96.3 (93.7-98.1) | 97.8 (95.6-99.1) |
≥4.5 mmol/l | 30 (6.6) | 72.5 (56.1-85.4) | 96.6 (94.0-98.3) | 96.6 (94.0-98.3) |
≥5.0 mmol/l | 26 (5.8) | 72.5 (56.1-85.4) | 97.5 (95.2-98.9) | 96.2 (94.1-98.3) |