Effect of appropriate dose, spectrum, and timing of antibiotics on 28-day mortality in patients with sepsis in the emergency department

Table 2 Comparison of primary and secondary outcomes between appropriate antibiotics (time, spectrum, dose) and inappropriate antibiotics groups

Outcomes	Appropriate antibiotics N=323	Inappropriate antibiotics N=270	Adjusted odds ratio^a Adjusted coefficient^b: Appropriate antibiotics	P value
Primary outcomes
28-day mortality, n (%)	12 (3.7%)	11 (4.1%)	0.57 (0.22, 1.44)^a	0.23
In-hospital mortality, n (%)	19 (5.9%)	17 (6.3%)	0.62 (0.29, 1.30)^a	0.21
28-day ventilator- free days, mean ± SD	26.35±5.13	26.13±6.06	0.01 (− 0.03, 0.05)^b	0.57
28-day hospital-free days, mean ± SD	20.70±8.30	20.27±9.17	0.03 (− 0.05, 0.11)^b	0.49

^aAdjusted odds ratio (95% confidence interval): qSOFA, respiratory rate, oxygen saturation
^bApply log transformation for the fitting model to normal distribution before Adjusted coefficient (mean difference): qSOFA, respiratory rate, oxygen saturation. After we did a log transform, 16 data of 28-day ventilator-free day and 57 data of 28-day hospital free day were missing because log [0] transformed to infinities. We had completed case analysis as 577 patients for 28-day ventilator-free day and 536 patients 28-day hospital free day outcomes
SD standard deviation, qSOFA quick Sequential Organ Failure Assessment

ISSN: 1865-1380