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Table 2 Comparison of primary and secondary outcomes between appropriate antibiotics (time, spectrum, dose) and inappropriate antibiotics groups

From: Effect of appropriate dose, spectrum, and timing of antibiotics on 28-day mortality in patients with sepsis in the emergency department

Outcomes Appropriate antibiotics
N=323
Inappropriate antibiotics
N=270
Adjusted odds ratioa
Adjusted coefficientb:
Appropriate antibiotics
P value
Primary outcomes
 28-day mortality, n (%) 12 (3.7%) 11 (4.1%) 0.57 (0.22, 1.44)a 0.23
 In-hospital mortality, n (%) 19 (5.9%) 17 (6.3%) 0.62 (0.29, 1.30)a 0.21
 28-day ventilator- free days, mean ± SD 26.35±5.13 26.13±6.06 0.01 (− 0.03, 0.05)b 0.57
 28-day hospital-free days, mean ± SD 20.70±8.30 20.27±9.17 0.03 (− 0.05, 0.11)b 0.49
  1. aAdjusted odds ratio (95% confidence interval): qSOFA, respiratory rate, oxygen saturation
  2. bApply log transformation for the fitting model to normal distribution before Adjusted coefficient (mean difference): qSOFA, respiratory rate, oxygen saturation. After we did a log transform, 16 data of 28-day ventilator-free day and 57 data of 28-day hospital free day were missing because log [0] transformed to infinities. We had completed case analysis as 577 patients for 28-day ventilator-free day and 536 patients 28-day hospital free day outcomes
  3. SD standard deviation, qSOFA quick Sequential Organ Failure Assessment