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Table 3 Diagnostic criteria of CHS and CWS

From: Cannabinoid hyperemesis syndrome and cannabis withdrawal syndrome: a review of the management of cannabis-related syndrome in the emergency department

CHS diagnostic criteria (Rome IV)

CWS diagnostic criteria (DSM-5)

Criteria fulfilled for the last 3 months with symptom onset at least 6 months before diagnosis

At least three criteria within one week of reducing or ceasing cannabis use should be present

Stereotypical episodic vomiting resembling cyclic vomiting syndrome (CVS) in terms of onset, duration, and frequency

Presentation after prolonged, excessive cannabis use

Relief of vomiting episodes by sustained cessation of cannabis use

Irritability; anger or aggression

Nervousness or anxiety

Sleep difficulty

Decreased appetite or weight loss

Restlessness

Depressed mood

Somatic symptoms causing significant discomfort

Supportive feature:

May be associated with pathologic bathing behavior (prolonged hot baths or showers)