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Table 3 Clinical features of poisoning involving central stimulant drugs – outpatient clinic patients

From: Poisoning with central stimulant drugs: an observational study from Oslo, Norway

 

Amphetamine n (%)

Cocaine n (%)

MDMA n (%)

Other n (%)

Multiple n (%)

Total n (%)

p value

Tachypnoea (RR ≥ 20/min)a

120 (16.0)

38 (19.4)

16 (22.5)

7 (17.5)

17 (22.4)

198 (17.5)

0.40

Bradypnoea (RR < 10/min)a

29 (3.9)

3 (1.5)

-

1 (2.5)

3 (3.9)

36 (3.2)

0.23

Tachycardia (HR ≥ 100/min)a

298 (39.8)

98 (50.0)

42 (59.2)

20 (50.0)

41 (53.9)

499 (44.1)

0.001

Bradycardia (HR < 50/min)a

9 (1.2)

1 (0.5)

1 (1.4)

-

-

11 (1.0)

0.80

Hypertension (SBP ≥ 180 mmHg)

2 (0.3)

1 (0.5)

1 (1.4)

-

-

4 (0.4)

0.32

Hypotension (SBP ≤ 90 mmHg)

21 (2.8)

3 (1.5)

1 (1.4)

1 (2.5)

1 (1.3)

27 (2.4)

0.85

Hyperthermia (tp ≥ 39.0 °C)

13 (1.7)

-

-

-

-

13 (1.1)

0.28

Level of consciousnessa,b

0.83

GCS score 15

417 (55.9)

119 (60.7)

38 (53.5)

22 (57.9)

46 (60.5)

642 (57.0)

GCS score 8–14

316 (42.4)

76 (38.8)

33 (46.5)

16 (42.1)

29 (38.2)

470 (41.7)

GCS score ≤ 7

13 (1.7)

1 (0.5)

-

-

1 (1.3)

15 (1.3)

Vomiting

21 (2.8)

15 (7.7)

9 (12.7)

2 (5.0)

6 (7.9)

53 (4.7)

 < 0.001

Headache

23 (3.1)

8 (4.1)

3 (4.2)

1 (2.5)

5 (6.6)

40 (3.5)

0.48

Anxiety

91 (12.2)

45 (23.0)

8 (11.3)

1 (2.5)

15 (19.7)

160 (14.1)

 < 0.001

Hallucinations

61 (8.2)

10 (5.1)

2 (2.8)

8 (20.0)

8 (10.5)

89 (7.9)

0.009

Agitation

208 (27.8)

47 (24.0)

17 (23.9)

24 (60.0)

18 (23.7)

314 (27.8)

 < 0.001

Psychosis

98 (13.1)

17 (8.7)

7 (9.9)

17 (42.5)

7 (9.2)

146 (12.9)

 < 0.001

Seizures

13 (1.7)

1 (0.5)

2 (2.8)

1 (2.5)

3 (3.9)

20 (1.8)

0.18

Palpitations

22 (2.9)

32 (16.3)

5 (7.0)

3 (7.5)

7 (9.2)

69 (6.1)

 < 0.001

Chest pain

35 (4.7)

40 (20.4)

1 (1.4)

1 (2.5)

7 (9.2)

84 (7.4)

 < 0.001

Arrhythmias

1 (0.1)

-

-

-

-

1 (0.1)

1.00

Total

748 (100)

196 (100)

71 (100)

40 (100)

76 (100)

1131 (100)

 
  1. GCS Glasgow Coma Scale, HR Heart rate, MDMA Methylenedioxymethamphetamine, RR Respiratory rate, SBP Systolic blood pressure, tp temperature
  2. aAt presentation
  3. bMissing: 4 (amphetamine 2, other 2)