Characteristics | All patients (n=978) | Dead (n=254) | Alive (n=724) | p-value |
---|---|---|---|---|
Age | 62.30±18.1 | 72.91±15.1 | 58.59±17.6 | <0.001 |
Sex (male) | 492 (50.3) | 149 (58.7) | 343 (47.4) | 0.002 |
Body mass index | 25.86±6.27 | 25.12±6.70 | 26.12±6.10 | 0.032 |
Day of symptoms | 4, 5 | 4, 3 | 4, 5 | 0.001 |
Underlying conditions | ||||
 Coronary artery disease | 90 (9.2) | 34 (13.4) | 56 (7.7) | 0.007 |
 Cerebrovascular disease | 92 (9.4) | 40 (15.7) | 52 (7.2) | <0.001 |
 Chronic pulmonary disease | 81 (8.3) | 29 (11.4) | 52 (7.2) | 0.035 |
 Diabetes mellitus | 323 (33) | 86 (33.9) | 237 (32.7) | 0.743 |
 Moderate to severe renal disease | 145 (14.8) | 63 (24.8) | 82 (11.3) | <0.001 |
 Cancer | 64 (6.5) | 23 (9.1) | 41 (5.7) | 0.060 |
 Immunodeficiency status | 30 (3.1) | 9 (3.5) | 21 (2.9) | 0.609 |
 Do-not-resuscitate status | 228 (23.3) | 163 (64.2) | 65 (9.0) | <0.001 |
 Charlson comorbidity index | 1, 3 | 2, 4 | 1, 2 | <0.001 |
Vital signs and mental status | ||||
 Systolic blood pressure (mmHg) | 136.53±28.95 | 136.64±30.20 | 136.49±28.5 | 0.942 |
 Diastolic blood pressure (mmHg) | 78.66±16.61 | 75.90±18.8 | 79.63±15.7 | 0.002 |
 Pulse rate (beats/min) | 95.71±19.07 | 98.94±21.4 | 94.58±19.0 | 0.002 |
 Respiratory rate (breaths/min) | 28, 12 | 32, 10 | 28, 10 | <0.001 |
 Body temperature (°C) | 36.9, 1.0 | 37.0, 1.2 | 36.9, 1.0 | 0.020 |
 Glasgow Coma Scale score | 15, 0 | 15, 1 | 15, 0 | <0.001 |
 Oxygen saturation (%) | 92, 11 | 88, 17 | 94, 7 | <0.001 |
Laboratory results | ||||
 Hemoglobin (g/dL) | 12.5, 2.8 | 12.2, 3.3 | 12.6, 2.6 | 0.013 |
 White blood cells (×103/μL) | 7.2, 4.8 | 7.3, 5.5 | 6.9, 4.5 | 0.012 |
 Platelet (×104/μL) | 21.6, 10.8 | 22.2, 11 | 20.3, 10.3 | <0.001 |
 Glomerular filtration rate (ml/min/1.73m2) | 64.65±33.71 | 52.08±29.4 | 74.53±33.5 | <0.001 |
 Lactate (mg/dL) | 0.52±1.51 | 1.71±2.9 | 0.42±1.0 | <0.001 |
 D-dimer (g/L) | 0.67, 1.69 | 0.961, 2.11 | 0.50, 1.24 | <0.001 |
 Aspartate transaminase (AST) (mg/dL) | 44, 39 | 52, 50 | 42, 38 | <0.001 |
 Alanine aminotransferase (ALT) (mg/dL) | 26, 27 | 28, 31 | 27, 33 | 0.717 |
 Total bilirubin (mg/dL) | 0.44, 0.36 | 0.50, 0.43 | 0.47, 0.34 | 0.128 |
 Procalcitonin (mg/L) | 0.20, 0.55 | 0.36, 1.31 | 0.15, 0.19 | <0.001 |
 C-reactive protein (μg/L) | 69.16, 87.4 | 82.4, 121.35 | 60.88, 90.84 | <0.001 |
Management | ||||
 Corticosteroids | 841 (86.2) | 242 (95.3) | 599 (83.0) | <0.001 |
 Favipiravir | 930 (95.2) | 238 (93.7) | 692 (95.7) | 0.197 |
 Remdesivir | 145 (14.8) | 56 (22.0) | 89 (12.3) | <0.001 |
 Tocilizumab | 54 (5.5) | 18 (7.1) | 36 (5.0) | 0.206 |
 Baricitinib | 12 (1.2) | 5 (2.0) | 7 (1.0) | 0.213 |
 High flow nasal cannula | 173 (17.7) | 63 (24.8) | 110 (15.2) | 0.001 |
 Endotracheal intubation | 155 (15.8) | 109 (42.9) | 46 (6.4) | <0.001 |
 Extracorporeal membrane oxygenation | 2 (0.2) | 2 (0.8) | 0 (0.0) | 0.017 |
 Inotropic drugs | 140 (14.3) | 108 (42.5) | 32 (4.4) | <0.001 |
 Renal replacement therapy | 45 (4.6) | 20 (7.9) | 25 (3.5) | 0.004 |
Emergency department disposition | ||||
 ICU | 95 (9.8) | 41 (16.2) | 54 (7.5) | <0.001 |
 Intermediate ward | 506 (52.1) | 157 (62.1) | 349 (48.5) | <0.001 |
 Low-acuity ward | 254 (26.1) | 25 (9.9) | 229 (31.8) | <0.001 |
 Field hospital | 44 (4.5) | 1 (0.4) | 43 (6.0) | <0.001 |
 aHospitel | 2 (0.2) | 0 (0.0) | 2 (0.3) | <0.001 |
 Home isolation | 32 (3.3) | 0 (0.0) | 32 (4.5) | <0.001 |
 Transfer | 8 (0.8) | 0 (0.0) | 8 (1.1) | <0.001 |
 Dead | 29 (3.0) | 29 (3.0) | 0 (0.0) | <0.001 |
 Other | 2 (0.2) | 0 (0.0) | 2 (0.3) | <0.001 |
Complications | ||||
 Ventilator associated pneumonia | 39 (4.0) | 24 (9.4) | 15 (2.1) | <0.001 |
 Hospital associated pneumonia | 125 (12.8) | 80 (31.5) | 45 (6.2) | <0.001 |
 Bacterial pneumonia | 170 (17.4) | 92 (36.2) | 78 (10.8) | <0.001 |
 Other hospital-acquired infection | 89 (9.1) | 38 (15.0) | 51 (7.0) | <0.001 |
 Septic shock | 137 (14.0) | 103 (40.6) | 34 (4.7) | <0.001 |
 Acute respiratory distress syndrome | 146 (14.9) | 104 (40.9) | 42 (5.8) | <0.001 |
 Pulmonary embolism | 29 (3) | 13 (5.1) | 16 (2.2) | 0.019 |
 Stroke | 6 (0.6) | 4 (1.6) | 2 (0.3) | 0.023 |
 Myocardial infarction | 7 (0.7) | 7 (2.8) | 0 (0.0) | <0.001 |
 Pneumothorax | 20 (2.0) | 11 (4.3) | 9 (1.2) | 0.003 |
Outcomes | ||||
 Hospital length of stay (days) | 10, 9 | 10, 12 | 10, 8 | 0.424 |
 ICU length of stay (days) | 8, 10 | 10, 10 | 7, 5 | 0.003 |