Characteristics | Age < 65 years (n=459) | Age > 65 years (n=519) | p-value |
---|---|---|---|
Age | 48.76±13.0 | 77.63±7.9 | n/a |
Sex (male) | 245 (53.4) | 247 (47.6) | 0.098 |
Body mass index | 27.37±6.9 | 24.20±5.1 | <0.001 |
Day of symptoms | 4, 5 | 3, 4 | 0.011 |
Underlying conditions | |||
  Coronary artery disease | 27 (5.2) | 63 (13.7) | <0.001 |
 Cerebrovascular disease | 22 (4.2) | 70 (15.3) | <0.001 |
 Chronic pulmonary disease | 34 (6.6) | 47 (10.2) | 0.037 |
 Diabetes mellitus | 137 (26.4) | 186 (40.5) | <0.001 |
 Moderate to severe renal disease | 46 (8.9) | 99 (21.6) | <0.001 |
 Cancer | 19 (3.7) | 45 (9.8) | <0.001 |
 Immunodeficiency status | 21 (4.0) | 9 (2.0) | 0.059 |
 Do-not-resuscitate status | 17 (3.3) | 32 (7.0) | 0.008 |
 Charlson comorbidity index | 0, 1 | 2, 4 | <0.001 |
Vital signs and mental status | |||
 Systolic blood pressure (mmHg) | 134.48±27.8 | 138.84±30.0 | 0.019 |
 Diastolic blood pressure (mmHg) | 80.90±16.8 | 76.13±16.1 | <0.001 |
 Pulse rate (beats/min) | 96, 24 | 92, 28 | 0.011 |
 Respiratory rate (breaths/min) | 28, 10 | 30, 12 | 0.005 |
 Body temperature (°C) | 36.8, 1.0 | 37.0, 1.1 | 0.049 |
 Glasgow Coma Scale score | 15, 0 | 15, 0 | <0.001 |
 Oxygen saturation (%) | 94, 8 | 92, 10 | <0.001 |
Laboratory results | |||
 Hemoglobin (g/dL) | 12.9, 2.5 | 12.1, 2.9 | 0.001 |
 White blood cells (×103/μL) | 6.9, 4.7 | 7.1, 4.5 | 0.247 |
 Platelet (×104/μL) | 22.5, 11.5 | 20.8, 10.4 | 0.016 |
 Creatinine (mg/dL) | 1.51±2.3 | 1.53±1.5 |  |
 Glomerular filtration rate (ml/min/1.73m2) | 81.20±34.8 | 54.95±26.9 | <0.001 |
 Lactate (mg/dL) | 0.61±1.88 | 1.00±1.90 | <0.001 |
 D-dimer (g/L) | 0.45, 1.08 | 0.87, 2.06 | <0.001 |
 Aspartate transaminase (AST) (mg/dL) | 45, 39 | 43, 42 | 0.342 |
 Alanine aminotransferase (ALT) (mg/dL) | 34, 35 | 24, 25 | <0.001 |
 Total bilirubin (mg/dL) | 0.47, 0.37 | 0.47, 0.35 | 0.278 |
 Procalcitonin (mg/L) | 0.16, 0.37 | 0.21, 0.66 | <0.001 |
 C-reactive protein (μg/L) | 61.98, 94.46 | 69.96, 101.76 | 0.045 |
Management | |||
 Corticosteroids | 419 (80.9) | 422 (92.1) | <0.001 |
 Favipiravir | 490 (94.6) | 440 (95.9) | 0.356 |
 Remdesivir | 66 (12.7) | 79 (17.2) | 0.050 |
 Tocilizumab | 31 (6.0) | 23 (5.0) | 0.506 |
 Baricitinib | 6 (1.2) | 6 (1.3) | 0.833 |
 High flow nasal cannula | 86 (16.6) | 87 (19) | 0.330 |
 Intubation | 78 (15.0) | 77 (16.8) | 0.455 |
 Extracorporeal membrane oxygenation | 1 (0.2) | 1 (0.2) | 0.932 |
 Inotropic drugs | 54 (10.4) | 86 (18.7) | <0.001 |
 Renal replacement therapy | 27 (5.2) | 18 (3.9) | 0.337 |
Emergency department disposition | |||
 ICU | 97 (18.7) | 88 (19.2) | 0.848 |
 Intermediate ward | 230 (44.7) | 276 (60.4) | <0.001 |
 Low-acuity ward | 169 (32.8) | 85 (18.6) | <0.001 |
 Field hospital | 29 (5.6) | 15 (3.3) | <0.001 |
 aHospitel | 2 (0.4) | 0 (0.0) | <0.001 |
 Home isolation | 19 (3.7) | 13 (2.8) | <0.001 |
 Transfer | 8 (1.6) | 0 (0.0) | <0.001 |
 Dead | 6 (1.2) | 23 (5.0) | <0.001 |
 Other | 2 (0.4) | 0 (0.0) | <0.001 |
Complications | |||
 Ventilator-associated pneumonia | 18 (3.5) | 21 (4.6) | 0.377 |
 Hospital-associated pneumonia | 49 (9.4) | 76 (16.6) | 0.001 |
 Bacterial pneumonia | 64 (12.3) | 106 (23.1) | <0.001 |
 Other hospital-acquired infection | 30 (5.8) | 59 (12.9) | <0.001 |
 Septic shock | 52 (10.0) | 85 (18.5) | <0.001 |
 Acute respiratory distress syndrome | 61 (11.8) | 85 (18.5) | 0.003 |
 Pulmonary embolism | 13 (2.5) | 16 (3.5) | 0.367 |
 Stroke | 1 (0.2) | 5 (1.1) | 0.073 |
 Myocardial infarction | 2 (0.4) | 5 (1.1) | 0.192 |
 Pneumothorax | 8 (1.5) | 12 (0.6) | 0.237 |
Outcomes | |||
 Hospital length of stay (days) | 10, 9 | 10, 9 | 0.474 |
 ICU length of stay (days) | 7, 8 | 9, 10 | 0.085 |
 Hospital mortality | 74 (14.3) | 180 (39.2) | <0.001 |