Table 4 Clinical features in the majority of the patients

Antinori et al. [3]

Asynchronous rash—genital area, inguinal lymphadenopathy; fever, asthenia, perianal lesions, inguinal lymphadenitis followed by anal lesions, lesions on feet, legs, back, suprapubic area and chest

Sukhdeo et al. [4]

Rectal pain, pustular rash involving the face, extremities, and torso; enlarged, painful, tender, cervical, and inguinal lymphadenopathy

Jang et al. [5]

Asymptomatic, perioral erosive lesions, tiny papules scattered across the back and lower abdomen, painless ulcer on the penile shaft, bilateral enlarged and tender inguinal lymph nodes, chills, sore throat, subjective fever followed by an extensive rash

Hammerschlag et al. [6]

Painless white pustules on his penis, fever, and malaise; the rash disseminated to his trunk, then sparingly to the face and limbs while the genital lesions crusted over

Tutu van Furth et al. [7]

Prodromal sore throat, gradually spreading lesions

Noe et al. [8]

Malaise, fever, joint pain, muscle and back pain, headache, dysphagia followed by white spots on tonsils

Perez Duque et al. [10]

Exanthem, inguinal lymphadenopathy, fever, and genital ulcers

Thornhill et al. [11]

Prodromal—fever, lethargy, myalgia, headache, lymphadenopathy; concomitant sexually transmitted illnesses followed by a rash, anogenital, and mucosal lesions

Inigo Martinez et al. [12]

Rash mainly anogenital, fever, asthenia, lymphadenopathy

Girometti et al. [13]

Fatigue or lethargy, fever, and skin lesions, with 51% of patients having anogenital lymphadenopathy

Català et al. [15]

Primary localized homogenous papules on skin or mucosa, generalized small pustules appeared later, mucosal ulcers and monkey whitlow less commonly

Oprea et al. [16]

Fever with chills, rectal pain, dysphagia, and vesiculopustular rash

Minhaj et al. [17]

Rash in the genital or perianal area, chills, fatigue, lymphadenopathy, fever

de Sousa et al. [18]

Disseminated papules throughout the trunk, face, and genital area and several clusters of umbilicated white papules in the shape of kissing lesions could be noticed on the perianal region

Peiró-Mestres et al. [19]

Fever, myalgia, generalized malaise, and skin lesions were present in more than one location of the body

Patel et al. [20]

Mucocutaneous lesions on genitals or perianal area, rectal pain, penile edema, sore throat, fever, myalgia, and lymphadenopathy

Tarín-Vicente et al. [21]

Skin lesions on anogenital, oral, and perianal areas, fever, headache, sore throat, and lymphadenopathy. In severe cases, proctitis and tonsillitis

Mileto et al. [22]

An ulcerated perianal lesion, two minor papular lesions on both elbows, asthenia, malaise, anorexia, lymphadenopathy, and a new lesion on the cheek that was accompanied by upper respiratory tract symptoms (sneezing and pharyngodynia)

Bížová et al. [23]

Fever, itchy rash on the forehead, and painless perianal erosions. Later, papulovesicular lesions on the forehead with lymphadenopathy appeared

Vallée et al. [24]

Fever with chills, fatigue, malaise, sore throat, anal pain, and lymphadenopathy

Raccagni et al. [25]

Diarrhea, tenesmus, two atypical nonvesicular erythematous cutaneous and perianal lesions

Bruno et al. [26]

Papules on buttocks, trunk, and umbilicus

de Nicolas-Ruanes et al. [27]

Initially started as proctitis, fever, headache, lymphadenopathy, generalized arthralgia, and myalgia. Later, on both arms and the dorsum of the hands, there was a maculopapular pinkish exanthem associated with many flat-topped umbilicated pustules with necrotic centers that later extended to the trunk, legs, face, and genitalia, sparing the palms and soles