Table 2 Diagnostic criteria for DIHS and SJS/TEN
The diagnostic criteria for DIHS | Day 6 | Day 14 |
1) Delayed erythema onset following administration of a limited number of medications, which rapidly enlarge and often progress to erythroderma | ✓ | ✓ |
2) Persistence for > 2 weeks after discontinuation of the causative agent | ✓ | |
3) Fever > 38 °C | ✓ | ✓ |
4) Hepatic dysfunction | ✓ | ✓ |
5) One or more of the following: | ||
a)Leukocyte proliferation > 11,000/mm3 b) Atypical lymphocytes (> 5%) or eosinophils (> 1500/mm3) | ✓ | ✓ |
6) Lymphadenopathy | ||
7) Reactivation of HHV-6 | ||
Typical DIHS meets all, and atypical DIHS meets (1)–(5) | ||
The diagnostic criteria for SJS/TEN | Day 6 | Day 14 |
1) Extensive mucosal involvement of the cutaneous-mucosal transition zone | ||
2) Erosions or blisters covering < 10% of the body surface area (SJS)/ > 10% (TEN) | ✓ | ✓ |
3) Fever up | ✓ | ✓ |
4) Necrotic changes in the epidermis on pathology | ||
5) Denial of severe forms of erythema multiforme | ✓ | ✓ |