Table 2 Previous case reports on dexmedetomidine overdose
From: A case report of an accidental iatrogenic dexmedetomidine overdose in an adult
Author | Publication | Year | Study type | Patient(s) | Environment | Dexmedetomidine dosage | Overdose symptoms | Treatment |
|---|---|---|---|---|---|---|---|---|
Jorden et al. [1] | Annals Pharmacotherapy | 2004 | Case-series | 1. 74-year-old male, 68 kg 2. 51-year-old male, 95 kg 3. 29-year-old male, 214 kg | 1. adjunct to general anesthesia 2. ICU sedation 3. ICU, weaning from respirator | 1. intravenous infusion (total 2,8 mcg/kg) 2. intravenous infusion 2–4 mcg/kg/h (total 19 mcg/kg) 3. intravenous infusion 0.5 mcg/kg/min (total 10 mcg/kg) | 1. mild hypotension and bradycardia 2. deep sedation 3. deep sedation | 1. observation 2. observation 3. observation |
Bernard et al. [4] | J Clin Anesthesia | 2009 | Case-report | 20-month-old female, 10.7Â kg | cardiac catheterization to close a patent ductus arteriosus | intravenous infusion 1 mcg/kg/min (total 36 mcg/kg) | hypoglycemia, hypertension, deep sedation | glucose correction, observation |
Nath et al. [3] | Indian J Anesthesia | 2013 | Case-report | 3-year-old male, 11Â kg | pyogenic meningitis | 100mcg as an intravenous bolus (total 9mcg/kg) | hypotension, miosis, profound sedation, bradypnea | oxygen supplementation by Venturi mask, saline boluses, adrenaline infusion |
Li et al. [2] | Pediatric Anesthesia | 2019 | Case-report | 23-month-old male, 12 kg | magnetic resonance imaging and neurosurgery | intravenous infusion 0.1–0.2 mcg/kg/min (total 22mcg/kg) | initial hypertension, bradycardia, hypotension | noradrenaline infusion |