Skip to main content

Onychomadesis in a 9-month-old boy with hand-foot-mouth disease



Nail abnormalities in childhood are generally uncommon. Recently, onychomadesis is described as a rare, late complication of hand-foot-mouth disease, which is a viral illness commonly seen in the pediatric age group. It is therefore important to elucidate the presentation of this entity, especially in the context of the hand-foot-mouth disease.

Case presentation

We report a case of onychomadesis in a 9-month old Lebanese boy who presented to the emergency department with rapidly progressing nail changes involving all four extremities. These changes appeared few days after the healing of cutaneous lesions of hand-foot-mouth disease.


This case highlights the importance of recognizing the association between onychomadesis and hand-foot-mouth disease in order to avoid unnecessary treatment and to reassure the patient’s parents.


Onychomadesis, characterized by shedding of nails from the proximal nail beds, is often idiopathic, but can also be linked to certain medications, systemic illnesses, and viral infections including hand-foot-mouth disease (HFMD). HFMD is a common contagious disease, affecting mainly children under the age of 10, but also reported in adults [1]. This disease is characterized by vesicular rashes on hands, feet, and buttocks and ulcers in the oral mucosa, accompanied by occasional fever [2]. Enterovirus 71 and coxsackievirus A16 are the most common causative agents associated with the condition [3]. Onychomadesis, a rare complication occurring 4 to 6 weeks after the onset of the disease, is usually self-limited and does not require treatment [4]. Common nail abnormalities include leukonychia and Beau lines as well as partial or complete nail shedding [5]. The mechanism of onychomadesis remains to be elucidated, although onychomadesis usually implies that nail matrix proliferation was temporarily inhibited. Bettoli et al. suggest that periungual inflammation secondary to viral infection may be induced directly by viruses or indirectly by immunocomplexes and consequent distal embolism [6], while Cabrerizo et al. consider that the nail matrix is directly damaged by viral replication, based on the presence of Coxsackie virus 6 in shed nails [7].

In this paper, we describe the presentation of onychomadesis in a boy previously diagnosed with HFMD.

Case presentation

A 9-month-old boy presented to the emergency department at a tertiary health care center in Beirut in September with a two-day history of nail shedding involving all four extremities. The patient began to have changes in the nails 6 days following the resolution of painful vesicles on the hands, feet, and mouth accompanied by mild fever (temperature 38.3 °C), diagnosed as HFMD. The oral blisters had been interfering with feeding; however, the patient did not receive any treatment besides supportive care, leading to the spontaneous resolution of the vesicles. Nail changes began as a greenish-yellowish patch appearing at the beginning of the nails and spreading towards the free edge. The nails then started to shed from the lunula towards the free edge concomitantly with the appearance of slowly growing new, pink nails (Fig. 1). Beau lines, horizontal grooves running across the nail plates, were noted (Fig. 2).

Fig. 1

New nail growth (black arrows) and greenish-yellowish patch (white arrows) in right hand

Fig. 2

Beau lines (yellow arrows) in left foot


To our knowledge, this is the first case of onychomadesis to be reported from the Middle East. We ought to highlight the importance of recognizing the association between HFMD and onychomadesis in order to avoid unnecessary treatment and to reassure the patient’s parents. Nevertheless, it is important to note that this is a rare presentation, and a thorough history and physical exam are necessary to identify the correct etiology and rule out other serious pathologies.


  1. 1.

    Irving S, Barclay-Buchanan C. Onychomadesis: a rare sequela of hand, foot, and mouth disease. J Emerg Med. 2015;49(4):e127–8.

    Article  PubMed  Google Scholar 

  2. 2.

    Aswathyraj S, Arunkumar G, Alidjinou EK, Hober D. Hand, foot and mouth disease (HFMD): emerging epidemiology and the need for a vaccine strategy. Med Microbiol Immunol. 2016;205(5):397–407.

    CAS  Article  PubMed  Google Scholar 

  3. 3.

    Yan X, Zhang ZZ, Yang ZH, Zhu CM, Hu YG, Liu QB. Clinical and etiological characteristics of atypical hand-foot-and-mouth disease in children from Chongqing, China: a retrospective study. BioMed Research International. 2015;26:2015.

    Google Scholar 

  4. 4.

    Guimbao J, Rodrigo P, Alberto MJ, Omenaca M. Onychomadesis outbreak linked to hand, foot, and mouth disease, Spain, July 2008. Euro Surveill. 2010;15(37):1.

    Google Scholar 

  5. 5.

    Hardin J, Haber RM. Onychomadesis: literature review. British J Dermatol. 2015;172(3):592–6.

    CAS  Article  Google Scholar 

  6. 6.

    Bettoli V, Zauli S, Toni G, Virgili A. Onychomadesis following hand, foot, and mouth disease: a case report from Italy and review of the literature. Int J Dermatol. 2013;52(6):728–30.

    Article  PubMed  Google Scholar 

  7. 7.

    Cabrerizo M, De Miguel T, Armada A, Martinez-Risco R, Pousa A, Trallero G. Onychomadesis after a hand, foot, and mouth disease outbreak in Spain, 2009. Epidemiol Infect. 2010;138(12):1775–8.

    CAS  Article  PubMed  Google Scholar 

Download references


No honorarium, grant, or other form of payment was given to anyone to produce the manuscript.

Author information




IM, RM, and MA prepared the literature review. IM was responsible for the manuscript writing, preparation, and submission. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Ibrahim Mortada.

Ethics declarations

Consent for publication

Written informed consent was obtained from the patient’s guardian/parent/next of kin for the publication of this report and any accompanying images.

Competing interests

The authors declare that they have no competing interest.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Mortada, I., Mortada, R. & Al Bazzal, M. Onychomadesis in a 9-month-old boy with hand-foot-mouth disease. Int J Emerg Med 10, 26 (2017).

Download citation


  • HFMD
  • Onychomadesis
  • Nail shedding
  • Infectious diseases
  • Dermatology