Skip to main content
  • Educational advances in emergency medicine
  • Open access
  • Published:

A Global Health Research Checklist for clinicians


Global health research has become a priority in most international medical projects. However, it is a difficult endeavor, especially for a busy clinician. Navigating the ethics, methods, and local partnerships is essential yet daunting.

To date, there are no guidelines published to help clinicians initiate and complete successful global health research projects. This Global Health Research Checklist was developed to be used by clinicians or other health professionals for developing, implementing, and completing a successful research project in an international and often low-resource setting. It consists of five sections: Objective, Methodology, Institutional Review Board and Ethics, Culture and partnerships, and Logistics. We used individual experiences and published literature to develop and emphasize the key concepts. The checklist was trialed in two workshops and adjusted based on participants’ feedback.


Discussions surrounding global health research priorities, methods, ethics, and governance have increased in recent decades following reports highlighting disparities in global research resource allocation, with an emphasis on local research capacity building, respect for local innovation, and global research priority setting [1,2,3].

In parallel, clinicians are increasingly interested in global health work as indicated by the increasing number of training programs with global health rotations or tracks and global health education publications [4,5,6]. In academic settings, clinicians aim to marry their global health clinical interests with academic research in order to increase their impact in their partner communities as well as their academic footprint, thereby developing an academic niche. However, performing research in a different country can be a daunting proposition for the busy clinician with limited time and funding, and maintaining such a research career may be difficult [7, 8].

To date, there are no guidelines published to specifically help clinicians initiate and complete successful global health research projects. We define a research project as successful if it reached publication and had a meaningful impact on the local community.

Therefore, we endeavored to develop a Global Health Research Checklist to be used by clinicians as a structure for developing, implementing, and completing a successful research project in an international and often low-resource setting.

The Global Pediatric Emergency Medicine Group (gPEM Group) at Children’s National Health Systems, George Washington University is a group of pediatric emergency medicine physicians with clinical and research experience in global health in various settings. Eight of us used a team approach based on our individual experiences to delineate the sections of the checklist. We used published literature to emphasize the key concepts as described below in detail. The checklist was trialed in two workshops including the Pediatric Academic Society meeting, Washington DC, and was adjusted based on participants’ feedback which included changes in structure, number of sections, examples, and content flow.

This checklist consists of five sections that can be tackled in any order (Table 1):

  1. 1.


  2. 2.


  3. 3.

    Institutional Review Board and Ethics

  4. 4.

    Culture and partnerships

  5. 5.


Table 1 Global health research checklist for clinicians

The five sections of the checklist

Two successful research projects [9,10,11] illustrate key concepts of the checklist and will be referred to in the discussion below (Table 2).

Table 2 Case illustrations


As with any sound research project, the first step is defining the research question and objectives. Generally, the project will grow out of personal interests or, preferably in global health, the needs of the local partner. A review of the literature will help identify work already done in the specified field as well as people who have worked in the area of research and the country of interest. Many professional organizations have interest groups to connect with those working in similar areas in global health [12]. Ideally, in global health settings where the territory and the system may be unfamiliar, the investigator should identify both published and unpublished studies and learn about successes and roadblocks previous investigators faced. Most importantly, the on-site partners must be involved and invited to give feedback on the value and acceptability of the project, and a formal needs assessment can be a valuable tool.

For example, in case one, RS initially aimed to study pre-hospital care but in response to the local partner’s needs, changed to study the emergency department.

Next, the investigator, together with on-site collaborators, should formulate specific objectives from the potential broad research questions. This may be a testable hypothesis, such as a new triage system will have less over-triage than the previous system (case two), or a may be a specific aim describing the training of providers caring for children in local emergency departments (case one).

Finally, the investigator is encouraged to consider the potential impact of the study being planned. These include answers to the following questions: Why is this question worth investigating? What are the potential implications on health outcomes of individual and of the community? Is there a possible impact beyond the population studied? What are the implications for the health resource utilization for the hospital or ministry of health? Will the implementation of this study drain the system or contribute to it?


While any study design may be applied to global health research, the methodology selected will depend on the available data sources, ethical considerations, and resource limitations. A structured planning tool, such as a logic model [13], will help ensure all necessary resources and desired outputs are considered and will provide a map of the project to share with collaborators. Table 3 lists examples of study designs with special considerations for a global health setting.

Table 3 Examples of study design: advantages and pitfalls in a global health setting

One priority is defining the study population. In a global setting, the local team’s input is invaluable to help understand the population and setting the investigator will be working in and how it will impact the study population.

Finally, the outcome specifies exactly what the study will measure. For example, to evaluate a new triage system, the investigator may want to measure how well the assigned triage level compares to the eventual disposition of the patients (case two). One could also measure staff satisfaction, length of stay, or in-hospital mortality. Using mortality as a measure can potentially show the importance of an intervention, but it can be difficult to demonstrate an impact and may require a larger sample size.

Institutional review boards and ethics

Significant discussion regarding the ethics of research in developing versus developed countries has occurred in recent decades, leading to the elaboration of guidelines specific to research in international settings [14,15,16]. These highlight the need to consider local cultures, economic capabilities, population needs, the local team’s right to innovation, and self-governance as well as long-term benefits and sustainability to the community studied [17, 18].

The principle of respect for persons emphasizes the individual’s right to self-determination and requires protection of those with a lower capacity for self-determination (e.g., children) [19]. Informed consent is an integral part of this principle and one that often causes complications in research implementation. For instance, in some societies, it is traditional and acceptable for the husband or another male relative to make decisions for a woman [14]. In others, the consent of community elders or senior family members must be sought before individual consent is obtained, if it is to be obtained at all [15]. Finally, illiteracy and cultural perceptions of western medicine may prove to be significant barriers to obtaining informed consent [20]. Discussions with local partners early on will be invaluable in understanding cultural implications of the proposed study and adjusting study design accordingly.

The principle of beneficence centers on non-maleficence and maximizing benefits while minimizing risk [19]. One controversy arising from the implementation of this principle for research in developing countries is the question of “standard of care,” i.e., should research studies in developing countries be required to provide the best available therapies (often standard of care in developed countries) as controls or should the standard of care in the local setting (frequently no or minimal therapy) be used? Such dilemmas have occurred frequently in published literature [20,21,22].

The principle of justice is exemplified by fairness of distribution. It requires appropriate selection of subjects and requires that the population in which the research study is being performed directly reap the benefits of the study [19]. Case 2 illustrates this principle: in Botswana, the host hospital was left with a new triage system uniquely designed specifically for it [10, 11].

To protect research subjects and follow the basic ethical principles outlined above, there is a requirement that proposed research studies be reviewed by independent bodies based on ethical merit and scientific validity [14, 15]. In principle, research should be held to high standards regardless of location. Generally, studies in developing countries involving cross-national collaborations require review by Institutional Review Boards (IRBs) (or Research Ethics Committees) in both the developed and developing countries [14]. Identifying IRBs in developing countries may be difficult. If not available at the host institution, IRBs may be available at nearby large educational institutions/universities. In addition, local or national Ministries of Health could provide such services. Finally, if after a good faith effort to locate an IRB, but one does not exist at all in the country of interest, guidelines exist to assist in establishing one specifically for the study in question (Table 4).

Table 4 Institutional review board resources

Culture and partnership(s)

Culture is pervasive in life, impacting every aspect of human behavior. The undertaking of a project in a different country where language, customs, religion, economic, and political climates all vary requires significant preparation [23]. A transparent relationship with a focus on humility and respect for the local partner’s culture is essential [24]. Sometimes, even a well thought out project may be affected by an unanticipated cultural misunderstanding [25,26,27,28,29].

In case one, RS had a rich understanding of the local culture given that she had lived there for many years. In creating the hospital surveys, since Arabic and English are the two languages utilized by most physicians, the team decided not to translate the survey in French, another main language in Lebanon. It was during the analysis that the word “resident” was noted to mean “someone who works in the hospital” for the physicians not trained in the US (or similar) medical system. This underscores the fact that even when a researcher has extensive knowledge about a culture, he or she may be from a different social class, ethnicity, or religion and therefore have a different understanding on certain issues and may not be aware of all the cultural variations within one nation.

In another unpublished example by LM, a project investigating the understanding of child abuse in Ghana was unsuccessful in getting local IRB approval because it was deemed to be too sensitive a topic with too many cultural implications for the local community.

Partnerships with local institutions, hospitals, or academic facilities are a necessary foundation to successful global health research projects. In creating a global health project, ideally, the first priority is to identify a local partner or institution that will serve as the “Local Champion” for the proposed project. This is often done over time, building a partnership individually or with a group. This long-term partnership is key to success as evidenced in the above-illustrated cases. Secondly, the project should be mutually beneficial to all parties involved and the identified partner should be equally committed and interested in the research project. In case two, the local team approached PM, highlighting their need and commitment. In academic settings, identifying partner priorities for research and offering authorship roles can be a motivating factor. Finally, delineating clear roles and expectations of both partners involved through memorandums of agreement/understanding (MOA/MOU) (Fig. 1) will provide concrete guidance for the project partnership. This could include responsibilities such as funding, housing, teaching, and authorship. Ideally, if these three key concepts are present then a successful partnership and a global health project are feasible [8, 30,31,32]. Table 5 presents priorities and pitfalls in creating durable and productive partnerships.

Fig. 1
figure 1

Example of a memorandum of understanding

Table 5 Priorities and pitfalls in creating durable and productive partnerships


The successful completion of an international project depends largely on logistical planning of timelines, budget, implementation, and manuscript publishing.

Timelines should include time for local partner identification, study design and development, data collection, and manuscript writing and submission. Careful planning should account for differing cultures and potential delays, such as availability of local partners and obtaining local IRB approval.

Expenses should be projected early in the project and funding options explored. Oftentimes, the pilot study may have to be funded by personal means. However, a partial list of potential funding agencies for clinicians is available in Table 6. Recently, Hansoti et al. described the potential funding opportunities available specifically for emergency medicine physicians working in international settings. This paper helps the reader navigate the complicated world of grants from seed to federal grants [33]. In addition, gaining the support of the principal investigator’s home institution can be critical in funding time and travel expenses, as well as finding home institution global research funds.

Table 6 Global Health Research Funding opportunities for clinicians

In planning for project implementation, health and safety travel preparedness should not be ignored. Research trip requirements can be found by visiting the public domains of the Centers for Disease Control and Prevention [34], the World Health Organization [35], the home country’s embassy website in the partner country as well as the partnering country’s embassy websites. Planning for the visiting members of the team with clear roles and check-in mechanisms is critical for both the safety and functionality of the team.


First, this checklist is limited by the fact that it is focused on clinicians and may not benefit other researchers involved in global health research such as public health providers. However, this is a deliberate choice, as it is a gap in the published literature and based on our prior experience an invaluable tool for our clinician colleagues.

Moreover, this checklist requires validation, which we will be undertaking.


We have delineated a comprehensive Global Health Research Checklist for clinicians, consisting of five sections that we have deemed necessary for a successful project. We believe that the checklist presented above is a valuable tool to plan and assess the feasibility of global health research projects. We have highlighted specific areas a clinician researcher should address when embarking on a global health research project. Figure 2 reproduces the checklist with specific questions to be used by the clinician researcher. Having developed this checklist based on experience and currently available literature, our future aim is to validate it.

Fig. 2
figure 2

Personal checklist


  1. Global Forum for Health Research, World Health Organization. The 10/90 (ten/ninety) report on health research 2001–2002. In: The global forum for health research; 2000. Accessed 9 Dec 2017.

    Google Scholar 

  2. Lee K, Mills A. Strengthening governance for global health research. BMJ. 2000;321:775–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. De Lisle H, Roberts, JH, Munro M, Jones L, Gyorkos T. The role of NGOs in global health research for development. Health Res Pol Syst. 2005;3:3.

  4. Dixon CA, Castillo J, Castillo H, Hom KA, Schubert C. Global health opportunities within pediatric subspecialty fellowship training programs: surveying the virtual landscape. BMC Med Educ. 2013;13:88.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Calland JF, Petroze RT, Abelson J, Kraus E. Engaging academic surgery in global health: challenges and opportunities in the development of an academic track in global surgery. Surgery. 2013;153(3):316–20.

    Article  PubMed  Google Scholar 

  6. Anspacher M, Frintner MP, Denno D, et al. Global health education for pediatric residents: a national survey. Pediatrics. 2011;128(4):e959–6.

    Article  PubMed  Google Scholar 

  7. Greyson SR, Richards AK, Coupet S, Desal MM, Padela AI. Global health experiences of US physicians: a mixed methods survey of clinician-researchers and health policy leaders. Glob Health. 2013;9:19.

    Article  Google Scholar 

  8. Ridde V, Capelle F. The global health research and the challenges of the North-South partnerships. Can J of Public Health. 2011;102(2):152–6.

    Google Scholar 

  9. Sawaya RD, Dayan P, Pusic MV, Nasri H, Kazzi AA. Pediatric preparedness of Lebanese emergency departments. J Emerg Med. 2013;44(6):1180–7.

    Article  PubMed  Google Scholar 

  10. Mullan PC, Torrey SB, Chandra A, Caruso N, Kestler A. Reduced overtriage and undertriage with a new triage system in an urban accident and emergency department in Botswana: a cohort study. Emerg Med J. 2014;31(5):356–60.

    Article  PubMed  Google Scholar 

  11. Twomey M, Mullan PC, Torrey SB, Wallis L, Kestler A. The Princess Marina Hospital accident and emergency triage scale provides highly reliable triage acuity ratings. Emerg Med J. 2012;29(8):650–3.

    Article  PubMed  Google Scholar 

  12. American Academic of Pediatrics, Section on International Child Health. Available at: Accessed on 9 Dec 2017.

  13. W.K. Kellogg Foundation. Logic Model Development Guide. Available at Accessed 1 Dec 2017.

  14. Calman KC. The ethics of research related to healthcare in developing countries. Oxford: Nuffield Council on Bioethics; 2002. p. 1–189.

    Google Scholar 

  15. Calman KC. The ethics of research related to healthcare in developing countries: follow-up. Oxford: Nuffield Council on Bioethics; 2004. p. 1–128.

    Google Scholar 

  16. Council for International Organizations of Medical Sciences. International ethical guidelines for biomedical research involving human subjects. Bull Med Ethics. 2002;182:17–23.

    Google Scholar 

  17. Lamonte R, Spiegel J. Setting global health research priorities. BMJ V. 2003;326:723–4.

    Article  Google Scholar 

  18. Ijsselmuiden CB, Kass NE, Sewankambo KN, Lavery JV. Evolving values in ethics and global health research. Global Public Health. 2010;5(2):154–63.

    Article  CAS  PubMed  Google Scholar 

  19. The National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research. The Belmont report––ethical principles and guidelines for the protection of human subjects of research. In: Office of Human Research Protection; 1979. Accessed 9 Dec 2017.

  20. Cash R, Wikler D, Saxena A, Capron A. Casebook on ethical issues in international health research. World Health Organization; 2009. Accessed 9 Dec 2017.

  21. Charatan F. Surfactant trial in Latin American infants criticized. BMJ. 2001;322:575.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Centers for Disease Control and Prevention (CDC). Administration of zidovudine during late pregnancy and delivery to prevent perinatal HIV transmission––Thailand, 1996–1998. MMWR Morb Mortal Wkly Rep. 1998;47(8):151–4.

    Google Scholar 

  23. Partners in Health. PIH Program Management Guide. In: Knowledge center global health discourse and tools; 2011. Accessed 9 Dec 2017.

  24. Riddle V, Capelle F. Global health research challenges with a North-South partnership. Can J Public Health. 2011;102(2):152–6.

    Google Scholar 

  25. Turner L. From the local to the global: bioethics and the concept of culture. J Med Philos. 2005;30:305–20.

    Article  PubMed  Google Scholar 

  26. Tseng, WS. (April 2004). Culture and psychotherapy: Asian perspectives. J Ment Health 2004; 13(2), 151–161.

  27. Patel V, Chowdhary N, Rahman A, Verdeli H. Improving access to psychological treatments: lessons from developing countries. Behav Res Ther. 2011;49(9):523–8.

    Article  PubMed  PubMed Central  Google Scholar 

  28. Ongugo K, Hall J, Attia J. Implementing tuberculosis control in Papua New Guinea: a clash of culture and science? J Community Health. 2011;36(3):423–30.

    Article  PubMed  Google Scholar 

  29. Storti C. Culture matters: the peace corps cross-cultural workbook. In: Peace corps information collection and exchange. Online edition; 2011.

    Google Scholar 

  30. Little M, Sisco C, Schappert J. The business of a better world. In: Working toward transformational health partnerships in low- and middle-income countries; 2012. Accessed 9 Dec 2017.

    Google Scholar 

  31. Caines K, Buse K, Carlson C, et al. Assessing the impact of global health partnerships. In: Department For International Development (DFID) health resource center; 2007. Accessed 9 Dec 2017.

    Google Scholar 

  32. Buse K, Hammer AM. Seven habits of highly effective global public-private health partnerships: practices and potential. Soc Sci Med. 2007;64(2):259–71.

    Article  PubMed  Google Scholar 

  33. Hansoti B, Levine A, Ganti L, et al. Funding global emergency medicine research––from seed grants to NIH support. Int J Emerg Med. 2016;9:27.

    Article  PubMed  PubMed Central  Google Scholar 

  34. Center for Disease Control and Prevention. Accessed 9 Dec 2017.

  35. World Health Organization. Accessed 9 Dec 2017.

  36. Hey SP, London AJ, Weijer C, Miller F. Is the concept of clinical equipoise still relevant to research? BMJ. 2017;359:j5787.

  37. Ressing M, Blettner M, Klug SJ. Data analysis of epidemiological studies: part 11 of a series on evaluation of scientific publications. Dtsch Arztebl Int. 2010;107(11):187–92.

    PubMed  PubMed Central  Google Scholar 

  38. Kimberlin CL, Winterstein AG. Validity and reliability of measurement instruments used in research. Am J Health Syst Pharm. 2008;65(23):2276–84.

    Article  PubMed  Google Scholar 

  39. Giacomini MK, Cook DJ. Users’ guides to the medical literature: XXIII. Qualitative research in health care a. Are the results of the study valid? Evidence-based medicine working group. JAMA. 2000;284(3):357–62.

    Article  CAS  PubMed  Google Scholar 

  40. Mennin S, Kalishman S, Eklund MA, Friedman S, Morahan PS, Burdick W. Project-based faculty development by international health professions educators: practical strategies. Med Teach. 2013;35(2):e971–7.

    Article  PubMed  Google Scholar 

  41. United States Department of Health and Human Services. Office for Human Research Projection (OHRP). Accessed 9 Dec 2017.

  42. Penslar RL, Institutional Review Board guidebook. 1993. Accessed 9 Dec 2017.

    Google Scholar 

  43. United States Department of Health & Human Services, The Office for Human Research Protection. Office for Human Research Protections (OHRP) Database for Registered IORGs & IRBs, Approved FWAs, and Documents Received in Last 60 Days. Accessed 9 Dec 2017.

  44. The Global Health Program for fellows and scholars. Fogarty International Center. National Institute of Health. Accessed Dec 2017.

  45. USAID global health fellows II. Accessed 9 Dec 2017.

  46. Funding opportunities. Fogarty International Center. Accessed 9 Dec 2017.

  47. Non-NIH funding opportunities for faculty. Fogarty International Center. Accessed 5 Mar 2018.

  48. Grant opportunities. Bill & Melinda Gates Foundation. Accessed 9 Dec 2017.

  49. Grant opportunities. Grand Challenges in Global Health. Accessed 9 Dec 2017.

  50. Pivot™. Accessed 9 Dec 2017.

  51. Active funding opportunities. National Science Foundation. Accessed 9 Dec 2017.

  52. Global health initiative––funding. Office of International Affairs. The Ohio State University. Accessed 6 Dec 2017.

  53. Rewarding innovative ideas. Grand Challenges in Global Health. The Bill and Melinda Gates Foundation. Accessed 9 Dec 2017.

  54. Funding agencies for global health opportunities. Center for Global Health. The University of Chicago. Accessed 9 Dec 2017.

  55. American Nurses Association. Opportunities for research funding. Accessed 9 Dec 2017.

Download references


Not applicable.


Not applicable.

Availability of data and materials

Data sharing not applicable to this article as no datasets were generated or analyzed during the current study.

Author information

Authors and Affiliations



RS generated the idea and contributed to the study design, literature search, figures, writing, editing, group organization, and submission of the manuscript. KB and OBK contributed to the study design, literature search, figures, writing, and editing of the manuscript. RS, LM, and PM contributed their case studies based on their research work. EA, JC, DG, LM, and PM all contributed equally to the study design, literature search, figures, and writing of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Rasha D. Sawaya.

Ethics declarations

Ethics approval and consent to participate

Not applicable.

Consent for publication

Not applicable.

Competing interests

The authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Sawaya, R.D., Breslin, K.A., Abdulrahman, E. et al. A Global Health Research Checklist for clinicians. Int J Emerg Med 11, 25 (2018).

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: