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The assessment of acute pulmonary embolism severity using CT angiography features

International Journal of Emergency Medicine volume 13, Article number: 15 (2020) Cite this article

Abstract

Background

This study was conducted to detect the association between radiologic features of CT pulmonary angiography (CTPA) and pulmonary embolism severity index (PESI).

Methods

A total of 150 patients with a definite diagnosis of PE entered the study. The CTPA feature including obstruction index, pulmonary trunk size, presence of backwash contrast, septal morphology, right ventricular (RV) and left ventricular (LV) dimensions, and RV/LV ratio were examined. The severity of the PE was estimated using PESI. The association between CTPA indices and PESI was measured. Statistical analysis was conducted using the SPSS software. P value < 0.05 was considered as statistically significant.

Results

A positive correlation was detected between the obstruction index and PESI (r = 0.45, P < 0.05). Moreover, PESI was significantly higher in patients with a more dilated pulmonary trunk (r = 0.20, P < 0.05). The backwash contrast and abnormal septal morphology were significantly more common among patients with higher PESI (P < 0.05). However, no significant correlation was detected between RV, LV, RV/LV, and PESI. The most predictor of high-risk PE was dilated pulmonary trunk with an odds ratio of 4.4.

Conclusion

Higher Obstruction index, dilated pulmonary trunk, presence of backwash contrast, and an abnormal septal morphology can be associated with a higher PESI.

Background

Pulmonary embolism (PE) is a type of thromboembolism that refers to obstruction of the main pulmonary artery or its branches. PE may cause various clinical presentations and even death. To reduce the morbidity and mortality caused by PE, an efficient diagnostic approach is needed for quick detection of the pathology in patients with suspected PE [1].

Computerized tomography pulmonary angiography (CTPA) is the gold standard technique in detecting PE with high sensitivity and specificity [2]. Since CTPA is the first imaging modality in detecting PE in susceptible patients, detecting predictive CTPA indices in identifying high-risk patients would be of high value to reduce the mortality rate [3].

PE can cause an increase in right ventricular (RV) afterload and dilation of RV. It may lead to a decreased LV function and output and a decrease in coronary artery supply. The reduction of blood flow to the coronary artery can cause RV dysfunction [4]. Radiologic features indicating RV dysfunction and PE severity includes RV dilation and increase the ratio of RV to left ventricular (LV) dimension, the size of pulmonary trunk, the presence of backwash contrast into inferior vena cava (IVC), and abnormal septal bowing [5,6,7]. The clot burden is another CTPA parameter that is shown to be associated with PE outcomes [5]. However, there are some studies reporting the clot burden score as a non-predictive index [7, 8].

Despite some studies conducted on the predictive value of CTPA indices on PE outcomes, the association between several CTPA measures of RV function and PE severity is still controversial. In this study, we aimed to detect the correlation between these indices and pulmonary embolism severity index (PESI) in patients diagnosed with PE.

Materials and methods

This was a retrospective cohort study that was conducted on patients with a diagnosis of PE in CTPA who were referred to the Radiology Department of Al-Zahra hospital, Isfahan University of Medical Sciences, Isfahan, Iran, between April 2018 and May 2019. Patients with age > 18 years, no history of thromboembolism, thrombolytic, and anticoagulant use were included in the study.

The study was approved by the ethics committee of the Radiology Department, Isfahan University of Medical Sciences, Isfahan, Iran. The purpose of the study was described to patients, and all participants provided written consent to participation.

All images were obtained using a 128-section multi-detector CT scanner based on the standard CTPA protocol for PE (detector width 40 mm, section thickness 0.625, rotation time 0.4 sec, 120 kVp, and 380 mAs) and 20 s after administration of 100 ml contrast media at a rate of 5 ml/sec.

CTPA indexes including obstruction index, RV and LV dimension, RV/LV ratio, pulmonary trunk size, presence of backwash contrast, septal bowing, and location of embolism were evaluated. The obstruction index was measured using the Qandali score [9]. RV and LV dimensions were measured just below the atrioventricular leaflets and described as the distance between the endocardium of the septum and each ventricular wall. The pulmonary trunk size was measured in millimeter and just before the division of the artery into two main branches. A transverse CT scan was used for evaluating the septal bowing. Interventricular septal morphology was considered as normal (convex toward right ventricle) or abnormal (straight or convex toward left ventricle). Based on the site of the obstruction, embolisms were categorized into three groups including the main pulmonary artery, lobar, and segmental arteries obstruction.

Pulmonary embolism severity index (PESI) was used to estimate the 30-day outcome and was obtained by summing the patient’s age in years and point assigned for each of the 10 predictors as follows: 10 points for male sex, 30 points for a history of cancer, 10 points for a history of heart failure, 10 points for a history of chronic lung disease, 20 points for tachycardia (pulse rate ≥ 110/min), 30 points for systolic blood pressure < 100 mmHg, 20 points for tachypnea (respiratory rate ≥ 30/min), 20 points for temperature < 36 °C, 60 points for an altered mental status, and 20 points for arterial oxygen saturation < 90% [10]. According to the PESI score, patients were categorized into five classes including class I (< 65 points: very low risk), class II (66–85 points: low risk), class III (86–105 points: intermediate risk), class IV (106–125 points: high risk), and class V (> 125 points: very high risk). Then, to facilitate the statistical analyses, they were categorized into two groups including low risk (class I, class II, and class III) and high risk (class IV and class V).

All statistical analyses were performed using the SPSS software, version 21 (SPSS Inc., Chicago, IL, USA). The mean ± standard deviation (SD) value was used for the analyses of quantitative variables. Frequency and percentage were used to represent qualitative variables. Pearson correlation, independent sample t test, and chi-square test were used to perform the analyses. Odds Ratio (OR) was reported for the effective variables. P < 0.05 was considered as the statistical significance level.

Results

In this study, 150 patients including 97 (64.7%) males and 53 (35.3%) females entered the study. The patients aged from 12 to 91 years old with a mean ± SD of 56.9 ± 17.9 years. The calculated PESI was ranged from 11 to 170 with a mean ± SD of 90.0 ± 30.1. None of the patients had hemodynamic instability and massive PE. Based on American Heart Association (AHA) classification, 90 (60%) and 60 (40%) patients had sub-massive and low-risk PE, respectively.

The mean of the obstruction index was 11.83 ± 8.40. A positive correlation was detected between PESI and obstruction index (r = 0.45, P < 0.001), and patients with high-risk PE had significantly higher PESI than those with low-risk PE (P < 0.05) (Table 1).

Table 1 The mean ± SD and frequency (%) of radiologic features in patients with low-risk and high-risk pulmonary embolism
Full size table

The pulmonary trunk had a minimum size of 17.00 and the maximum size of 41.00 with a mean of 27.08 ± 4.18. Pulmonary trunk size equal to less than 29 was detected in 110 patients. The other 40 individuals had a dilated pulmonary trunk (> 29 mm). An increase in the PESI was detected with the increase in pulmonary trunk size (r = 0.20, P < 0.05). The high-risk PE was significantly more common among patients with a dilated pulmonary artery (OR = 4.4, P < 0.05) (Table 2).

Table 2 The Odds ratio of different CTA indices in predicting pulmonary embolism severity
Full size table

RV/LV ranged from 0.53 to 13.28 with a mean of 1.01 ± 1.07. The mean troponin and D-dimer serum levels were 78.74 ± 145.26 and 3806.42 ± 12446.37, respectively. No correlation was detected between PESI and RV (P = 0.778), LV (P = 0.595), RV/LV (P = 0.857), troponin level (P = 0.141), and D-dimer level (P = 0.846).

Backwash contrast into IVC was detected among 67 (44.7%) of individuals. PESI was significantly higher in patients with backwash contrast than those without a backwash contrast (P < 0.05) (Table 1). The presence of backwash contrast was significantly different among patients with low-risk and high-risk PE (P < 0.05) with a higher rate of backwash contrast in patients with high-risk PE.

Interventricular septum bowed to the right side in 91 (60.7%) of patients, while bowing to left, and straight septum was detected in 5 (3.3%) and 54 (36.0%) of individuals, respectively. The frequency of patients with abnormal interventricular septal morphology was significantly higher among patients with high-risk PE (P < 0.05).

PESI was significantly lower in patients with segmental artery PE than those with lobar or main artery PE (P < 0.05). However, no significant difference was detected between PESI in PEs located in the main and lobar pulmonary arteries (P = 0.233).

Discussion

This study was conducted on 150 patients with an approved PE diagnosis to detect the CTPA indices indicating the PE with higher PESI. We found the obstruction index, the pulmonary trunk size, the presence of backwash contrast into IVC, and the abnormal septal morphology as predictive factors of higher PESI. We also investigated the dilated pulmonary trunk as the most effective predictor.

Among the signs included in the study, backwash contrast was significantly correlated with PESI. The result, in concordance with other studies, reported the presence of mentioned sign as a risk factor for mortality [11,12,13]. The backwash contrast into IVC is due to a right ventricular dysfunction that leads to tricuspid valve dysfunction, a decrease in forward flow from the right ventricle, and an increase of blood stasis in central veins. In addition to studies reflecting the presence of backwash contrast as a sign of RV dysfunction, some published articles have suggested this sign as an unreliable predictor [14, 15].

In this study, an abnormal septal morphology was significantly more common among patients with a high-risk PE. Interventricular septal morphology is caused by an increase of right ventricular pressure secondary to PE. It sometimes causes a leftward shift of interventricular septum that may lead to a decrease in left ventricular filling and a reduction of cardiac output, causing right ventricular wall ischemia, impaired heart function, and a poor prognosis for patients with PE [16].

In the present study, pulmonary trunk size was positively correlated with PESI. Patients with high-risk PE had significantly higher pulmonary trunk diameter. In this study, the value of 29 mm was established for the maximal value for normal pulmonary artery diameter. Also, we found that the dilated pulmonary artery had the highest OR = 4.4 in comparison with other predictors including abnormal septal morphology or the presence of backwash contrast. It suggests the idea that pulmonary trunk size can be used as a factor in prediction of patients with high-risk PE. The association between pulmonary artery diameter and short-term clinical outcomes was observed in a report of Lyhne et al. However, they did not report the pulmonary artery diameter as a strong predictor of PE outcomes [14].

There are many studies on the association between RV/LV ratio and PE outcomes. RV/LV ratio greater than 0.9 in the short axis was proposed as a sign of poor outcome and a higher 30-day risk of mortality [17,18,19]. However, there are some other studies reporting higher cutoff points including 1, 1.2, and 1.5 for the RV/LV ratio to be reported as an independent predictor of PE mortality [20,21,22]. Meinel et al. reported RV/LV diameter ratio as the strongest predictor of the clinical outcome of PTE [23]. However, we did not find any association between RV/LV ratio and PESI, which is in accordance with the report of Lyhne et al. [14]. The different results in different studies indicate that further studies are needed on this subject.

In addition to clinical symptoms and imaging features, there are many laboratory tools that are frequently utilized in patients with suspected PE, including arterial blood gas, brain natriuretic peptide, troponin, and D-dimer. These tests are not diagnostic, but they may have some prognostic values [24, 25]. In this study, we did not find any correlation between troponin, D-dimer level, and PESI. These results are in concordance with the report of Lerche et al., who stated that troponin level is not correlated to thrombotic obstruction and severity of PE [26]. However, they found a correlation between D dimer and clot burden. Meanwhile, in the present study, D dimer was not correlated with CBS and the PESI.

Although this study identified CTA indices related to higher PESI in patients with stable hemodynamic, it cannot be generalized to all patients with PE. None of the participants in this study had a massive PE. Another study is needed to identify the predictive features of CTA in patients with hemodynamic instability.

Conclusions

In conclusion, this study suggests the CTPA indices including obstruction index, presence of backwash contrast, dilated pulmonary trunk, and presence of an abnormal septal bowing as indicators of high PESI. The physicians can use these imaging features to distinguish high-risk patients and make effective therapeutic managements.

Availability of data and materials

The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.

Abbreviations

PE:

Pulmonary embolism

CTPA:

Computed tomography pulmonary angiography

PESI:

Pulmonary embolism severity index

RV:

Right ventricle

LV:

Left ventricle

References

  1. Agnelli G, Becattini C. Acute pulmonary embolism. N Engl J Med. 2010;363(3):266–74.

    Article  CAS  Google Scholar 

  2. Moroni C, Bartolucci M, Vanni S, Peiman N, Bartolini M, Miele V, editors. Prognostic value of CT pulmonary angiography (CTPA) parameters in acute pulmonary embolism (CTPA) parameters in acute pulmonary embolism (APE)2017: European Congress of Radiology 2017.

  3. Albrecht MH, Bickford MW, Nance JW Jr, Zhang L, De Cecco CN, Wichmann JL, et al. State-of-the-art pulmonary CT angiography for acute pulmonary embolism. Am J Roentgenol. 2017;208(3):495–504.

    Article  Google Scholar 

  4. Bryce YC, Perez-Johnston R, Bryce EB, Homayoon B, Santos-Martin EG. Pathophysiology of right ventricular failure in acute pulmonary embolism and chronic thromboembolic pulmonary hypertension: a pictorial essay for the interventional radiologist. Insights into imaging. 2019;10(1):18.

    Article  Google Scholar 

  5. Jeebun V, Doe S, Singh L, Worthy S, Forrest I. Are clinical parameters and biomarkers predictive of severity of acute pulmonary emboli on CTPA? QJM. 2009;103(2):91–7.

    Article  Google Scholar 

  6. Nural M, Elmali M, Findik S, Yapici O, Uzun O, Sunter A, et al. Computed tomographic pulmonary angiography in the assessment of severity of acute pulmonary embolism and right ventricular dysfunction. Acta Radiol. 2009;50(6):629–37.

    Article  CAS  Google Scholar 

  7. Bach AG, Nansalmaa B, Kranz J, Taute B-M, Wienke A, Schramm D, et al. CT pulmonary angiography findings that predict 30-day mortality in patients with acute pulmonary embolism. Eur J Radiol. 2015;84(2):332–7.

    Article  Google Scholar 

  8. Vedovati M, Germini F, Agnelli G, Becattini C. Prognostic role of embolic burden assessed at computed tomography angiography in patients with acute pulmonary embolism: systematic review and meta-analysis. J Thromb Haemost. 2013;11(12):2092–102.

    Article  CAS  Google Scholar 

  9. Qanadli SD, El Hajjam M, Vieillard-Baron A, Joseph T, Mesurolle B, Oliva VL, et al. New CT index to quantify arterial obstruction in pulmonary embolism: comparison with angiographic index and echocardiography. Am J Roentgenol. 2001;176(6):1415–20.

    Article  CAS  Google Scholar 

  10. Donzé J, Le Gal G, Fine MJ, Roy P-M, Sanchez O, Verschuren F, et al. Prospective validation of the pulmonary embolism severity index. Thromb Haemost. 2008;100(05):943–8.

    Article  Google Scholar 

  11. Ghaye B, Ghuysen A, Willems V, Lambermont B, Gerard P, D'Orio V, et al. Severe pulmonary embolism: pulmonary artery clot load scores and cardiovascular parameters as predictors of mortality. Radiology. 2006;239(3):884–91.

    Article  Google Scholar 

  12. Moroni A-L, Bosson J-L, Hohn N, Carpentier F, Pernod G, Ferretti GR. Non-severe pulmonary embolism: prognostic CT findings. Eur J Radiol. 2011;79(3):452–8.

    Article  Google Scholar 

  13. Furlan A, Aghayev A, Chang C-CH, Patil A, Jeon KN, Park B, et al. Short-term mortality in acute pulmonary embolism: clot burden and signs of right heart dysfunction at CT pulmonary angiography. Radiology. 2012;265(1):283–93.

    Article  Google Scholar 

  14. Lyhne MD, Schultz JG, MacMahon PJ, Haddad F, Kalra M, Tso DM-K, et al. Septal bowing and pulmonary artery diameter on computed tomography pulmonary angiography are associated with short-term outcomes in patients with acute pulmonary embolism. Emerg Radiol. 2019;26(6):623–30.

    Article  Google Scholar 

  15. Collomb D, Paramelle P, Calaque O, Bosson J, Vanzetto G, Barnoud D, et al. Severity assessment of acute pulmonary embolism: evaluation using helical CT. Eur Radiol. 2003;13(7):1508–14.

    Article  CAS  Google Scholar 

  16. Konstam MA, Kiernan MS, Bernstein D, Bozkurt B, Jacob M, Kapur NK, et al. Evaluation and management of right-sided heart failure: a scientific statement from the American Heart Association. Circulation. 2018;137(20):e578–622.

    Article  Google Scholar 

  17. Chaosuwannakit N, Makarawate P. Prognostic value of right ventricular dysfunction and pulmonary obstruction index by computed tomographic pulmonary angiography in patients with acute pulmonary embolism. J Med Assoc Thai. 2012;95(11):1457.

    PubMed  Google Scholar 

  18. Terluk AD, et al. Echocardiographic Predictors of Long-Term Mortality in Patients Presenting With Acute Pulmonary Embolism. Am J Cardiol. 2019;124(2):285–91.

  19. Gupta R, Fortman DD, Morgenstern DR, Cooper CJ. Short-and long-term mortality risk after acute pulmonary embolism. Curr Cardiol Rep. 2018;20(12):135.

    Article  Google Scholar 

  20. Kang DK, Sun JS, Park KJ, Lim HS. Usefulness of combined assessment with computed tomographic signs of right ventricular dysfunction and cardiac troponin T for risk stratification of acute pulmonary embolism. Am J Cardiol. 2011;108(1):133–40.

    Article  Google Scholar 

  21. Hefeda MM, Elmasry MM. Prediction of short term outcome of pulmonary embolism: parameters at 16 multi-detector CT pulmonary angiography. Egypt J Radiol Nuclear Med. 2014;45(4):1089–98.

    Article  Google Scholar 

  22. Singanayagam A, Chalmers JD, Scally C, Akram AR, Al-Khairalla MZ, Leitch L, et al. Right ventricular dilation on CT pulmonary angiogram independently predicts mortality in pulmonary embolism. Respir Med. 2010;104(7):1057–62.

    Article  Google Scholar 

  23. Meinel FG, Nance JW Jr, Schoepf UJ, Hoffmann VS, Thierfelder KM, Costello P, et al. Predictive value of computed tomography in acute pulmonary embolism: systematic review and meta-analysis. Am J Med. 2015;128(7):747–59. e2.

    Article  Google Scholar 

  24. Horlander KT, Leeper KV. Troponin levels as a guide to treatment of pulmonary embolism. Curr Opin Pulm Med. 2003;9(5):374–7.

    Article  CAS  Google Scholar 

  25. Kline JA, Hernandez-Nino J, Newgard CD, Cowles DN, Jackson RE, Courtney DM. Use of pulse oximetry to predict in-hospital complications in normotensive patients with pulmonary embolism. Am J Med. 2003;115(3):203–8.

    Article  Google Scholar 

  26. Lerche M, Bailis N, Akritidou M, Meyer HJ, Surov A. Pulmonary vessel obstruction does not correlate with severity of pulmonary embolism. J Clin Med. 2019;8(5):584.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Radiology, Isfahan University of Medical Sciences, Isfahan, Iran

    Azin Shayganfar, Somayeh Hajiahmadi, Mohsen Astaraki & Shadi Ebrahimian

  2. Al-Zahra Hospital, Hezar Jerib Avenue, Isfahan, Iran

    Shadi Ebrahimian

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All the authors contributed in data gathering, statistical analysis, and writing the manuscript. The final version of the manuscript was approved by all authors.

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Correspondence to Shadi Ebrahimian.

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The project was approved by the ethical review board of Radiology Department, Isfahan University of Medical Sciences, Isfahan, Iran.

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Shayganfar, A., Hajiahmadi, S., Astaraki, M. et al. The assessment of acute pulmonary embolism severity using CT angiography features. Int J Emerg Med 13, 15 (2020). https://doi.org/10.1186/s12245-020-00272-2

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Keywords

International Journal of Emergency Medicine

ISSN: 1865-1380

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